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P0500

Sigma-Aldrich

棕榈酸

≥99%

别名:

C16:0, NSC 5030, 十六酸, 棕榈酸

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About This Item

线性分子式:
CH3(CH2)14COOH
CAS号:
57-10-3
分子量:
256.42
Beilstein:
607489
EC號碼:
200-312-9
MDL號碼:
MFCD00002747
分類程式碼代碼:
12352106
PubChem物質ID:
24898107
NACRES:
NA.25

蒸汽壓力

10 mmHg ( 210 °C)

品質等級

200

化驗

≥99%

形狀

powder

bp

271.5 °C/100 mmHg (lit.)

mp

61-62.5 °C (lit.)

密度

0.852 g/mL at 25 °C (lit.)

官能基

carboxylic acid

脂質類型

saturated FAs

運輸包裝

ambient

儲存溫度

room temp

SMILES 字串

CCCCCCCCCCCCCCCC(O)=O

InChI

1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)

InChI 密鑰

IPCSVZSSVZVIGE-UHFFFAOYSA-N

基因資訊

human ... FABP2(2169) , FABP3(2170) , FABP4(2167) , FABP5(2171)

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相关类别

一般說明

棕榈酸（PA）是一种存在于人体内的饱和脂肪酸，占膜磷脂（PL）和脂肪三酰甘油（TAG）中总脂肪酸（FA）的20-30%。它是棕榈油的主要成分之一，在肉类和乳制品、可可脂和橄榄油中也发现了大量的PA。母乳中也含有PA。PA在细胞和组织水平上执行各种基本的生物学功能。

應用

棕榈酸已用于：
  • 研究对单核细胞趋化蛋白-1（MCP-1）在脂肪细胞和THP-1巨噬细胞中表达的影响
  • 刺激原代大鼠肝细胞脂毒性
  • 在牛血清白蛋白（BSA）溶液中加入维甲酸（RA）和视黄醇，研究对精子发生和减数分裂进程的影响

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

nwg

閃點（°F）

235.4 °F

閃點（°C）

113 °C

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

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Jorge Matias Caviglia et al.
Journal of lipid research, 52(9), 1636-1651 (2011-07-02)
Although short-term incubation of hepatocytes with oleic acid (OA) stimulates secretion of apolipoprotein B100 (apoB100), exposure to higher doses of OA for longer periods inhibits secretion in association with induction of endoplasmic reticulum (ER) stress. Palmitic acid (PA) induces ER
Songtao Li et al.
Biochimica et biophysica acta, 1841(1), 22-33 (2013-09-24)
Saturated fatty acids (SFAs) induce hepatocyte cell death, wherein oxidative stress is mechanistically involved. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a master transcriptional regulator of cellular antioxidant defense enzymes. Therefore, Nrf2 activation is regarded as an effective strategy against
Chen Shen et al.
Journal of cellular and molecular medicine, 22(7), 3572-3581 (2018-04-20)
Lipotoxicity induced by saturated fatty acids (SFAs) plays a pathological role in the development of non-alcoholic fatty liver disease (NAFLD); however, the exact mechanism(s) remain to be clearly elucidated. Toll-like receptor (TLR) 4 plays a fundamental role in activating the
Jonas Sieber et al.
The American journal of pathology, 183(3), 735-744 (2013-07-23)
Type 2 diabetes mellitus is characterized by dyslipidemia with elevated free fatty acids (FFAs). Loss of podocytes is a hallmark of diabetic nephropathy, and podocytes are highly susceptible to saturated FFAs but not to protective, monounsaturated FFAs. We report that
B Vessby et al.
Diabetologia, 37(10), 1044-1050 (1994-10-01)
Recent data indicate that peripheral insulin sensitivity may be influenced by dietary fat quality and skeletal muscle phospholipid fatty acid composition. During a health survey of 70-year-old men insulin sensitivity was measured by the euglycaemic hyperinsulinaemic clamp technique and the
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