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Merck

O8264

Sigma-Aldrich

Anti-Orai1 兔抗

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

别名:

CRACM1, Calcium release-activated calcium channel protein 1, TMEM142A, Transmembrane protein 142A

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

antigen ~35 kDa (non-glycosylated)
antigen ~50 kDa (glycosylated)

物種活性

human

濃度

~1.0 mg/mL

技術

western blot: 1-2 μg/mL using whole extract of human HEK-293T cells expressing ORAI1

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... ORAI1(84876)
mouse ... Orai1(109305)

一般說明

ORAI calcium release-activated calcium modulator 1 (ORAI1) is the pore-forming subunit of the Ca2+ release-activated (CRAC) channel. The protein possesses four predicted transmembrane domains and intracellular amino and carboxyl-terminal domains. The ORAI1 gene is localized on human chromosome 12q24.31.

免疫原

synthetic peptide corresponding to amino acids 288-301 of human ORAI1, conjugated to KLH. The corresponding sequence differs by 2 amino acids in rat and mouse.

應用

Anti-ORAI1 antibody produced in rabbit has been used in immunohistochemistry and Western blotting.

生化/生理作用

ORAI calcium release-activated calcium modulator 1 (ORAI1) modulates Ca2+ entry into cells. The channel is activated by stromal interaction molecule-1 (STIM-1). Mutation in the gene encoding the protein has been linked to late-onset tubular aggregate myopathy and congenital miosis.

外觀

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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其他客户在看

Store-operated Ca2+ Entry Mediated by Orai1 and TRPC1 Participates to Insulin Secretion in Rat ?-Cells*
Jessica S
The Journal of Biological Chemistry (2015)
Yukari Endo et al.
Human molecular genetics, 24(3), 637-648 (2014-09-18)
The store-operated Ca(2+) release-activated Ca(2+) (CRAC) channel is activated by diminished luminal Ca(2+) levels in the endoplasmic reticulum and sarcoplasmic reticulum (SR), and constitutes one of the major Ca(2+) entry pathways in various tissues. Tubular aggregates (TAs) are abnormal structures
Microdeletion of 12q24.31: Report of a Girl With Intellectual Disability, Stereotypies, Seizures and Facial Dysmorphisms
Orazio Palumbo
American Journal of Medical Genetics. Part A (2014)
Changbo Zheng et al.
Frontiers in pharmacology, 8, 222-222 (2017-05-11)
Cardiac hypertrophy is a major risk factor for heart failure, which are among the leading causes of human death. Gastrodin is a small molecule that has been used clinically to treat neurological and vascular diseases for many years without safety
Calcium Influx of Mast Cells Is Inhibited by Aptamers Targeting the First Extracellular Domain of Orai1
Renshan Sun
PLoS ONE (2016)

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