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Merck

O2136

Sigma-Aldrich

油酸酰胺

≥99% (TLC), powder, sleep-inducing brain lipid

别名:

顺式-9,10-十八碳烯酰胺, 顺式-9-十八烯胺, 油酸酰胺

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About This Item

经验公式(希尔记法):
C18H35NO
CAS号:
分子量:
281.48
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

产品名称

油酸酰胺, ≥99%

品質等級

化驗

≥99%

藥物控制

regulated under CDSA - not available from Sigma-Aldrich Canada

儲存溫度

−20°C

SMILES 字串

CCCCCCCC\C=C/CCCCCCCC(N)=O

InChI

1S/C18H35NO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H2,19,20)/b10-9-

InChI 密鑰

FATBGEAMYMYZAF-KTKRTIGZSA-N

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一般說明

油酰胺是脂质或大脑脂肪酸,可在CSF(脑脊液)中找到。最初得自剥夺睡眠的猫的脑脊液。

應用

油酰胺已用作葡萄糖和半乳糖培养基中的补充剂,用于防止半乳糖诱导Leigh综合征。

生化/生理作用

油酰胺有促进睡眠的效果。它拥有多种属性,如大麻素类活性。油酰胺也可通过大鼠神经胶质细胞间隙连接阻断通信。
睡眠诱导脑脂质,其变构调节GABAA受体并增强5-HT7血清素受体反应。大鼠和人类CB1大麻素受体的选择性内源性激动剂。

危險聲明

防範說明

危險分類

Aquatic Chronic 4

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

404.6 °F - closed cup

閃點(°C)

207 °C - closed cup

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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分析证书(COA)

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The sleep-inducing lipid oleamide deconvolutes gap junction communication and calcium wave transmission in glial cells
Guan X, et al.
The Journal of Cell Biology, 139(7), 1785-1792 (1997)
Oleamide and anandamide effects on food intake and sexual behavior of rats
Martinez-Gonzalez D, et al.
Neuroscience Letters, 364(1), 1-6 (2004)
Andrea Herrera-Solís et al.
Pharmacology, biochemistry, and behavior, 95(1), 106-112 (2010-01-09)
Anandamide and oleamide, induce sleep when administered acutely, via the CB1 receptor. Their subchronic administration must be tested to demonstrate the absence of tolerance to this effect, and that the sudden withdrawal of these endocannabinoids (eCBs) does not affect sleep
Edgar Soria-Gómez et al.
The international journal of neuropsychopharmacology, 13(9), 1247-1254 (2010-07-29)
The central nervous system control of food intake has been extensively studied, hence, several neurotransmitter systems regulating this function are now clearly identified, for example, the endocannabinoid and serotoninergic systems. The former stimulates feeding while the latter inhibits it. Oleamide
Gayong Shim et al.
Journal of controlled release : official journal of the Controlled Release Society, 155(1), 60-66 (2010-10-26)
Oligolysine-based cationic lipid derivatives were synthesized for delivery of siRNA, and formulated into cationic liposomes. Among various oligolysine-based lipid derivatives differing in lysine residue number and lipid moiety, trilysinoyl oleylamide (TLO)-based liposomes (TLOL) showed the highest delivery efficiency combined with

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