推荐产品
化驗
≥98% (HPLC)
形狀
solid
溶解度
H2O: ≥20 mg/mL
儲存溫度
room temp
SMILES 字串
Cl.CN(C)CC\C=C1\c2ccccc2COc3ccc(CC(O)=O)cc13
InChI
1S/C21H23NO3.ClH/c1-22(2)11-5-8-18-17-7-4-3-6-16(17)14-25-20-10-9-15(12-19(18)20)13-21(23)24;/h3-4,6-10,12H,5,11,13-14H2,1-2H3,(H,23,24);1H/b18-8-;
InChI 密鑰
HVRLZEKDTUEKQH-NOILCQHBSA-N
基因資訊
human ... HRH1(3269)
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生化／生理作用
奥洛他定是一种组胺 H1 受体拮抗剂和肥大细胞稳定剂。大脑中的 H1 受体占位级别较低解释了奥洛他定镇静作用较低的原因。一般认为奥洛他定是 P-糖蛋白的底物，限制了其脑渗透。
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 3 Oral - Aquatic Acute 1
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Ping Zhu et al.
Journal of analytical toxicology, 35(2), 113-118 (2011-03-15)
A sensitive and rapid method based on liquid chromatography- tandem mass spectrometry (MS-MS) was developed for the determination of olopatadine in human plasma. Sample preparations were carried out by protein precipitation with the addition of acetonitrile followed by liquid-liquid extraction
Pharmacokinetic evaluation of olopatadine for the treatment of allergic rhinitis and conjunctivitis.
Andrew S Nickels et al.
Expert opinion on drug metabolism & toxicology, 7(12), 1593-1599 (2011-10-29)
Olopatadine hydrochloride is an antihistamine and mast cell stabilizer available in three forms, including oral, intranasal and ocular preparations. Most of the practical applications focus on the use of olopatadine for the treatment of allergic rhinitis and conjunctivitis via intranasal
Eli O Meltzer et al.
Allergy and asthma proceedings, 32(3), 213-220 (2011-04-12)
Allergic rhinitis (AR) is highly prevalent in children. Olopatadine, 0.6% nasal spray (olopatadine) is approved for the relief of seasonal allergic rhinitis (SAR) symptoms in children 6 years of age and older. The objective of this study is to provide
Fuad M Baroody et al.
American journal of rhinology & allergy, 27(1), 48-53 (2013-02-15)
Nasal allergen challenge (NAC) leads to a nasal ocular reflex, which is augmented by allergic inflammation. This study was designed to confirm our previous observation that an intranasal steroid inhibits the nasal ocular reflex and to show that histamine does
Peter K Smith et al.
American journal of rhinology & allergy, 25(4), e149-e152 (2011-08-09)
Vasomotor rhinitis (VMR) is a hypersensitivity syndrome with heightened reactivity to environmental triggers. Twenty-two patients with severe VMR were treated nasally with either normal saline or 0.6% olopatadine and challenged nasally with a hyperosmolar mannitol solution. Treatment with 0.6% olopatadine
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