N3040

Necrostatin-7

≥98% (HPLC), powder

• 别名: 5-[[3-(4-Fluorophenyl)-1H-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-4-thiazolidinone, Nec-7
• 经验公式（希尔记法）: C₁₆H₁₀FN₅OS₂
• CAS号: 351062-08-3
• 分子量: 371.41
• MDL號碼: MFCD02334728
• 分類程式碼代碼: 12352202
• PubChem物質ID: 329818601

属性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 儲存條件: desiccated
• 顏色: yellow to tan
• 溶解度: DMSO: >10 mg/mL (with warming)
• 儲存溫度: 2-8°C
• SMILES 字串: Fc1ccc(cc1)-c2n[nH]cc2C=C3SC(=N)N(C3=O)c4nccs4
• InChI: 1S/C16H10FN5OS2/c17-11-3-1-9(2-4-11)13-10(8-20-21-13)7-12-14(23)22(15(18)25-12)16-19-5-6-24-16/h1-8,18H,(H,20,21)
• InChI 密鑰: SMJGLNVGTJLIRV-UHFFFAOYSA-N

说明

生化／生理作用

Necrostatin-7 (Nec-7) is a potent inhibitor of necroptosis, a regulated caspase-independent necrotic cell death pathway, distinct from apoptosis. Nec-7 has a different profile from the other necrostatins as it does not inhibit RIP1 kinase, suggesting the possibility that it may target an additional as yet unknown regulatory molecule in the pathway.

Necrostatin-7 is a potent inhibitor of necroptosis.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 防範說明: P264 - P270 - P301 + P312 - P501
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable