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應用
N-亚硝基二乙胺（NDEA）已被用作肝致癌物/DNA损伤剂。它已被用作气液色谱的校准标准品。
生化／生理作用
N-亚硝基二乙胺（NDEA）是一种有效的肝癌性二烷基亚硝胺。它主要存在于烟草烟雾、水、切达干酪、腌制油炸食品和许多酒精饮料中。NDEA与DNA修复/复制相关的核酶的变化相关。它会导致所有动物物种中的多种肿瘤。其主要靶器官是鼻腔、气管、肺、食道和肝脏。
包裝
包装于100mL带有硅/PTFE胶垫和铝质撕裂密封的血清瓶中。
注意
通过注入任何相容的溶剂可在不暴露内容物的情况下制备任何所需强度的溶液。
重構
将内容物溶解在100mL溶剂中，可得到1％的溶液。
法律資訊
Isopac is a registered trademark of Merck KGaA, Darmstadt, Germany
ISOPAC
产品编号
说明
价格
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 3 Oral - Aquatic Chronic 3 - Carc. 1B
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
個人防護裝備
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Proteomic profiling of expression of proteasomal subunits from livers of mice treated with diethylnitrosamine.
Yuan F
Proteomics, 13, 389-389 (2013)
Chemopreventive effect of hydroethanolic extract of Euphorbia neriifolia leaves against DENA-induced renal carcinogenesis in mice.
Pracheta P
Asian Pacific Journal of Cancer Prevention, 12, 677-677 (2011)
The detection of DNA adducts (risk factors for DNA damage). A method for genomic DNA, the results and some effects of nutritional intervention.
Howard JM
Journal of Nutritional & Environmental Medicine, 12, 19-31 (2002)
Yewei Liu et al.
International journal of cancer, 143(7), 1817-1828 (2018-05-01)
To better inform the next clinical trials of vascular disrupting agent combretastatin-A4-phosphate (CA4P) in patients with hepatic malignancies, this preclinical study aimed at evaluating CA4P therapeutic efficacy in rats with primary hepatocellular carcinomas (HCCs) of a full spectrum of differentiation
Potential chemoprevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by polyphenolics from Acacia nilotica bark.
Singh BN
Chemico-Biological Interactions, 181, 20-20 (2009)
商品
DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.
实验方案
US EPA Method 8270 (Appendix IX): GC Analysis of Semivolatiles on Equity®-5 (30 m x 0.25 mm I.D., 0.50 μm)
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