推荐产品
品質等級
化驗
≥99.0% (GC)
形狀
liquid
IVD
for in vitro diagnostic use
bp
177 °C (lit.)
密度
0.95 g/mL (lit.)
官能基
N-nitroso
amine
nitroso
SMILES 字串
CCN(CC)N=O
InChI
1S/C4H10N2O/c1-3-6(4-2)5-7/h3-4H2,1-2H3
InChI 密鑰
WBNQDOYYEUMPFS-UHFFFAOYSA-N
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應用
N-亚硝基二乙胺可作为反应物用于合成：
- 在 HCl 环境下通过可见光诱导的光加成反应从烯烃中生成α-氨基肟衍生物。
- 在二氯甲烷环境下从金属卟啉生成二乙基亚硝胺金属卟啉络合物。
N-Nitrosodiethylamine can also be used in the synthesis of 1,1-diethylhydrazine.
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 3 Oral - Aquatic Chronic 3 - Carc. 1B
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
個人防護裝備
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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L Verna et al.
Pharmacology & therapeutics, 71(1-2), 57-81 (1996-01-01)
N-Nitrosodiethylamine (NDEA) is DNA reactive after bioactivation and produces tumors in every animal species tested. Bioactivation is effected by several P450 isozymes including CYP2E1, which is ethanol inducible. Tumor formation in rat liver was proportional to O4-ethyldeoxythymidine formation in DNA
Esther Bertran et al.
Hepatology (Baltimore, Md.), 58(6), 2032-2044 (2013-07-03)
Transforming growth factor-beta (TGF-β) is an important regulatory suppressor factor in hepatocytes. However, liver tumor cells develop mechanisms to overcome its suppressor effects and respond to this cytokine by inducing other processes, such as the epithelial-mesenchymal transition (EMT), which contributes
Masaaki Miyakoshi et al.
Molecular carcinogenesis, 53(1), 67-76 (2012-08-23)
STAT3 activation is involved in development and progression of hepatocellular carcinoma (HCC). We investigated STAT3 activation during hepatocarcinogenesis induced by neonatal diethylnitrosamine (DEN) treatment in mice. Nuclear accumulation and phosphorylation of STAT3 were detected in altered hepatocyte foci in the
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