推荐产品
product name
MDR1/BCRP Double Knockout Caco-2 Cells, one vial
生物源
human male colorectal tissue (Source disease: adenocarcinoma)
形狀
liquid
技術
drug transporter assay: suitable
permeability assay: suitable
應用
ADME/TOX
儲存溫度
−196°C
基因資訊
human ... ABCB1(5243) , ABCG2(9429)
一般說明
應用
Transporter Function in Caco-2 Cells with Targeted P-Glycoprotein, MRP2 and BCRP Gene Knockout Using Zinc Finger Nucleases
Comparison of Function and Relative Transporter Protein Concentrations in Caco-2 Cells with Single and Double Knockouts of the ABCB1, ABCG2, and ABCC2 Genes
Caco-2 Transporter Knockout Cell Based Assays
特點和優勢
- A functional double knockout of the MDR1 gene and BCRP gene eliminates the reliance on chemical inhibitors to determine if a compound is an MRP2 substrate
- The vial format enables the MDR1 and BCRP knockout cells to be included in standard drug transporter protocols
- Human assay with no interference from animal inhibitors
- Overcome the limitations of RNAi and knockdown cell lines that arise from remaining transporter functionality
免責聲明
儲存類別代碼
10 - Combustible liquids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
商品
Application note on Drug transport assays in a 96-well system using Millicell-96 System from Millipore.
Utilize these Caco-2 cell based assay tools for screening small molecule drug compounds prior to clinical studies and submission to regulatory agencies.
We presents an article on The Role of Intestinal Efflux Transporters In Drug Absorption.
We presents an article on The Role of Intestinal Efflux Transporters In Drug Absorption.
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