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用途
sufficient for 100 colorimetric or fluorometric tests
檢測方法
colorimetric
fluorometric
相關疾病
gastrointestinal diseases; cancer
儲存溫度
−20°C
基因資訊
human ... PKLR(5313) , PKM2(5315)
mouse ... PKLR(18770) , PKM2(18746)
rat ... PKLR(24651) , PKM2(25630)
一般說明
丙酮酸是代谢中的中心分子，其通过多种代谢途径进行使用和合成，其中包括糖酵解和丙氨酸的氨基转移作用。丙酮酸可在柠檬酸循环中进一步氧化，在糖异生期间转化为碳水化合物，或还原为乳酸。高水平的丙酮酸与肝脏疾病和遗传性疾病有关。丙酮酸也被用于刺激代谢，从而导致体重减轻。
適合性
适于测定血液、组织、培养细胞等多种生物样品中的丙酮酸浓度。
原則
由偶联酶测定法测定丙酮酸浓度，得到的比色（570nm）/荧光（λex = 535/λem =587 nm）产物与存在丙酮酸成比例。
訊號詞
Danger
危險聲明
危險分類
Aquatic Chronic 3 - Resp. Sens. 1 - Skin Sens. 1
儲存類別代碼
10 - Combustible liquids
Changes in muscle cell metabolism and mechanotransduction are associated with myopathic phenotype in a mouse model of collagen VI deficiency.
De Palma S, et al.
PLoS ONE, 8(2), e56716-e56716 (2013)
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eLife, 11 (2022-03-16)
In times of environmental change species have two options to survive: they either relocate to a new habitat or they adapt to the altered environment. Adaptation requires physiological plasticity and provides a selection benefit. In this regard, the Western honeybee
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Antioxidants & redox signaling, 24(17), 1013-1028 (2016-02-26)
Carbon monoxide is a respiratory poison and gaseous signaling molecule. Although CO-releasing molecules (CORMs) deliver CO with temporal and spatial specificity in mammals, and are proven antimicrobial agents, we do not understand the modes of CO toxicity. Our aim was
Abstracts of the XVIth International Conference on Biological Inorganic Chemistry, July 22-26, 2013, Grenoble, France.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 19 Suppl 1, 1-696 (2014-03-13)
Astrocytic metabolic switch is a novel etiology for Cocaine and HIV-1 Tat-mediated neurotoxicity.
Natarajaseenivasan K, et al.
Cell Death & Disease, 9(4), 415-415 (2018)
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We presents an article about the Warburg effect, and how it is the enhanced conversion of glucose to lactate observed in tumor cells, even in the presence of normal levels of oxygen. Otto Heinrich Warburg demonstrated in 1924 that cancer cells show an increased dependence on glycolysis to meet their energy needs, regardless of whether they were well-oxygenated or not.
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