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用途
sufficient for 100 colorimetric tests
檢測方法
colorimetric
相關疾病
cancer
儲存溫度
−20°C
一般說明
富马酸是琥珀酸脱氢酶氧化琥珀酸形成的三羧酸(TCA)循环中间体。在哺乳动物肝脏中，富马酸盐也是尿素循环的产物，其在细胞质中的释放导致其转化为苹果酸盐，随后转化成草酰乙酸盐，同时在细胞质中生成 NADH。富马酸盐水合酶的缺乏与富马酸盐的细胞浓度增加和肾细胞癌的发病率升高有关。这很可能是由富马酸盐介导的 HIF1 上调引起的。Fumarate 检测试剂盒是灵敏地检测各种样品中富马酸的便利的工具。
應用
Fumarate 检测试剂盒已用于测定样品中富马酸的浓度。
適合性
适用于检测各种样品中的富马酸盐，包括组织、细胞和血清
原則
通过酶测定法测定富马酸盐，其产生与存在的富马酸盐成比例的比色（450nm）产物。
訊號詞
Danger
危險聲明
危險分類
Eye Dam. 1 - Skin Corr. 1B
儲存類別代碼
8A - Combustible corrosive hazardous materials
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Combined effects of FH (E404D) and ACOX2 (R409H) cause metabolic defects in primary cardiac malignant tumor.
Zhou X, et al.
Cell Death & Disease, 5(1), 18-18 (2018)
Yijing Zhuang et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 39(4), 1307-1316 (2016-09-09)
Motility is a feature of many pathogens that contributes to the migration and dispersion of the infectious agent. Whether gentamycin has a post-antibiotic effect (PAE) on the swarming and swimming motility of Escherichia coli (E. coli) remains unknown. In this
Melatonin alleviates adipose inflammation through elevating α-ketoglutarate and diverting adipose-derived exosomes to macrophages in mice.
Liu Z, et al.
Journal of Pineal Research, 64(1), e12455-e12455 (2018)
Meixi Peng et al.
Cell death & disease, 10(3), 228-228 (2019-03-10)
Citrate, a substance being related to de novo fatty acid synthesis and tricarboxylic acid (TCA) cycle, has a pivotal role in cell survival. However, the molecular mechanisms that regulate intracellular citrate in triple-negative breast cancer (TNBC), especially under hypoxic condition
Ping Li et al.
International journal of molecular sciences, 23(3) (2022-02-16)
The FH gene encodes the fumarate hydratase of the Krebs cycle and functions as a homotetramer to catalyze the hydration of fumarate to malate. Mutations in FH result in uterine leiomyomas, a rare autosomal dominant inherited metabolic disease. However, how
商品
Sigma-Aldrich presents an article about how proliferatively active cells require both a source of carbon and of nitrogen for the synthesis of macromolecules. Although a large proportion of tumor cells utilize aerobic glycolysis and shunt metabolites away from mitochondrial oxidative phosphorylation, many tumor cells exhibit increased mitochondrial activity.
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