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Merck
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主要文件

M8693

Sigma-Aldrich

Melanotan II 乙酸盐

≥95% (HPLC)

别名:

Ac-[Nle4Asp5D-Phe7Lys10]α-MSH-(4-10)-NH2

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About This Item

经验公式（希尔记法）:
C50H69N15O9 · xC2H4O2
CAS号:
121062-08-6
分子量:
1024.18 (free base basis)
MDL號碼:
MFCD06795842
分類程式碼代碼:
51111800
NACRES:
NA.32

品質等級

200

化驗

≥95% (HPLC)

形狀

lyophilized solid

顏色

white

溶解度

H2O: soluble 5 mg/mL

運輸包裝

dry ice

儲存溫度

−20°C

InChI

1S/C50H69N15O9/c1-3-4-16-36(59-29(2)66)44(69)65-41-25-42(67)55-20-11-10-18-35(43(51)68)60-47(72)39(23-31-26-57-34-17-9-8-15-33(31)34)63-45(70)37(19-12-21-56-50(52)53)61-46(71)38(22-30-13-6-5-7-14-30)62-48(73)40(64-49(41)74)24-32-27-54-28-58-32/h5-9,13-15,17,26-28,35-41,57H,3-4,10-12,16,18-25H2,1-2H3,(H2,51,68)(H,54,58)(H,55,67)(H,59,66)(H,60,72)(H,61,71)(H,62,73)(H,63,70)(H,64,74)(H,65,69)(H4,52,53,56)/t35-,36-,37-,38+,39-,40-,41-/m0/s1

InChI 密鑰

JDKLPDJLXHXHNV-MFVUMRCOSA-N

基因資訊

human ... MC3R(4159) , MC4R(4160)
mouse ... MC3R(17201) , MC4R(17202)
rat ... MC3R(29310) , MC4R(25635)

Amino Acid Sequence

Ac-Nle-Asp-His-Phe-Arg-Trp-Lys-NH2

一般說明

Melanotan II诱导黑色素生成，从而增加皮肤色素沉着。是α-黑素细胞刺激素的类似物。

應用

Melanotan II乙酸盐已被用于研究其对大鼠进食和能量消耗的抑制作用。

生化／生理作用

Melanotan II 是一种 MC3-R/MC4-R 黑皮质素激动剂。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
026M4750V
025M4770V
072M4733V
091M4715V
100M4735V

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Kristian Thestrup-Pedersen et al.
Ugeskrift for laeger, 173(13), 975-975 (2011-04-02)
A 25-year-old man had self-injected more than 150 doses of melanotan to increase his skin pigmentation, which had increased significantly. At the same time, his nevi had become darker and new nevi and lentigines developed; they also occurred on his
[Eruptive dysplastic nevi following melanotan use].
L Hueso-Gabriel et al.
Actas dermo-sifiliograficas, 103(4), 329-331 (2012-03-20)
Zeng-You Ye et al.
Regulatory peptides, 166(1-3), 112-120 (2010-10-13)
Sympathetic nerve activity is increased in obesity-related hypertension. However, the central mechanisms involved in the increased sympathetic outflow remain unclear. The hypothalamic melanocortin system is important for regulating energy balance and sympathetic outflow. To understand the mechanisms by which the
Inhibitory Effect of the Melanocortin Receptor Agonist Melanotan-II (MTII) on Feeding Depends on Dietary Fat Content and not Obesity in Rats on Free-Choice Diets
Jose K
Frontiers in Behavioral Neuroscience (2015)
John-Paul Baird et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 301(4), R1044-R1056 (2011-07-08)
Injections of the melanocortin 3/4 receptor (MCR) agonist melanotan II (MTII) to a variety of brain structures produces anorexia, suggesting distributed brain MCR control of food intake. We performed a detailed analysis of feeding behavior (licking microstructure analysis) after a
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