所有图片(1)
About This Item
经验公式（希尔记法）:
C14H11N · HCl
CAS号:
分子量:
229.70
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推荐产品
化驗
≥98% (HPLC)
形狀
powder
顏色
off-white to light tan
溶解度
DMSO: 10 mg/mL, clear
儲存溫度
room temp
SMILES 字串
Cl.Cc1cccc(n1)C#Cc2ccccc2
InChI
1S/C14H11N.ClH/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13;/h2-9H,1H3;1H
InChI 密鑰
PKDHDJBNEKXCBI-UHFFFAOYSA-N
基因資訊
human ... GRIN2B(2904) , GRM5(2915)
rat ... Grm5(24418)
一般說明
GRIN2B（谷氨酸离子型受体NMDA型2B亚基）编码N-甲基d-天门冬氨酸受体2B亚型（GluN2B）。它属于N-甲基-D-天冬氨酸受体（NMDAR）基因家族。它定位于染色体12p13.1。
應用
6-甲基-2-（苯基乙炔基）吡啶盐酸盐已被用于研究3，4（±）亚甲二氧基甲基苯丙胺（MDMA）是否可以通过mGlu5受体影响小鼠胚胎干细胞（mESC）的自我更新。
生化／生理作用
GRIN2B（谷氨酸离子型受体NMDA型2B亚基）在神经元的生长中起重要作用，对于学习和记忆至关重要。GRIN2B突变与精神分裂症、帕金森′病和双相情感障碍等神经精神疾病和发育疾病有关。MPEP（2-甲基-6-（苯基乙炔基）吡啶盐酸盐）用于治疗阿尔茨海默′病（AD）。
高选择性、非竞争性 mGluR 5 代谢型谷氨酸受体拮抗剂。
特點和優勢
该化合物是《受体分类及信号转导》手册上谷氨酸受体（G蛋白家族）页面上的特色化合物。想要浏览手册的其他页面， 请单击此处。
这种化合物是神经科学研究的特色产品。点击此处发现更多特色神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
José Luis Albasanz et al.
ACS chemical neuroscience, 7(12), 1690-1697 (2016-09-17)
Due to phylogenetic proximity to the human, zebrafish has been recognized as a reliable model to study Alzheimer's disease (AD) and other central nervous system disorders. Furthermore, metabotropic glutamate receptors have been previously reported to be impaired in brain from
Human GRIN2B variants in neurodevelopmental disorders
Hu C, et al.
Journal of Pharmacological Sciences, 132(2), 115-121 (2016)
Li Rebekah Feng et al.
Translational psychiatry, 8(1), 110-110 (2018-06-01)
Cancer-related fatigue (CRF) is a common burden in cancer patients and little is known about its underlying mechanism. The primary aim of this study was to identify gene signatures predictive of post-radiotherapy fatigue in prostate cancer patients. We employed Fisher
Geehoon Chung et al.
Scientific reports, 7(1), 9743-9743 (2017-08-31)
Patients with chronic pain easily accompany the negative mood symptoms such as depression and anxiety, and these disturbances in turn affect the aversive perception of pain. However, the underlying mechanisms are largely unknown. We hypothesized that the alteration of metabotropic
Mélanie Cavalier et al.
Neurochemical research, 44(3), 609-616 (2018-01-22)
Maternal immune challenge has proved to induce moderate to severe behavioral disabilities in the offspring. Cognitive/behavioral deficits are supported by changes in synaptic plasticity in different brain areas. We have reported previously that prenatal exposure to bacterial LPS could induce
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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