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产品名称
髓鞘少突胶质细胞糖蛋白肽片段35-55, immunodominant epitope of MOG
品質等級
化驗
≥97% (HPLC)
形狀
powder
顏色
white
應用
cell analysis
儲存溫度
−20°C
基因資訊
mouse ... Mog(17441)
rat ... Mog(24558)
相关类别
Amino Acid Sequence
Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys
一般說明
髓鞘少突胶质细胞糖蛋白（MOG）是中枢神经系统的组成部分，存在于少突胶质细胞和髓鞘的表面。它的细胞外结构域被广泛用于创建多发性硬化的自身免疫动物模型。在大鼠中，MOG表达于海马体中。
應用
- Delayed administration of erythropoietin and its non-erythropoietic derivatives ameliorates chronic murine autoimmune encephalomyelitis.: This paper investigates the delayed therapeutic administration of erythropoietin and its derivatives in the treatment of autoimmune encephalomyelitis, using Myelin Oligodendrocyte Glycoprotein Peptide Fragment 35-55 to induce the disease model in mice (Savino et al., 2006).
- Absence of reuptake of serotonin influences susceptibility to clinical autoimmune disease and neuroantigen-specific interferon-gamma production in mouse EAE.: This research explores the role of serotonin reuptake in modulating immune responses and susceptibility to autoimmune diseases, using Myelin Oligodendrocyte Glycoprotein Peptide Fragment 35-55 to induce experimental autoimmune encephalomyelitis in mice (Hofstetter et al., 2005).
- Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis.: The study demonstrates the effectiveness of trichostatin A, a histone deacetylase inhibitor, in treating experimental autoimmune encephalomyelitis. Myelin Oligodendrocyte Glycoprotein Peptide Fragment 35-55 was used to induce the disease model in rats and mice, providing insights into potential epigenetic therapies (Camelo et al., 2005).
生化／生理作用
诱导啮齿动物的实验性自身免疫性脑脊髓炎模型；单次注射这种肽，可产生复发-缓解型神经系统疾病，表现出大量斑块状脱髓鞘病症；免疫接种MOG（35-55），能抑制MPTP损伤的多巴胺能神经元的自发再生功能。
其他說明
从0.1％TFA水溶液中冻干
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Oligodendrocyte myelin glycoprotein (OMgp) in rat hippocampus is depleted by chronic ethanol consumption.
Okamoto H
Neuroscience Letters, 406(1-2), 76-80 (2006)
Ewa Balkowiec-Iskra et al.
Acta neurobiologiae experimentalis, 63(2), 109-115 (2003-08-21)
The pathological process of neurodegeneration is accompanied by an inflammatory reaction that is believed to contribute to the pathogenesis of neurodegenerative diseases. The aim of our study was to evaluate the influence of autoimmune reaction induced by post-traumatic vaccination with
Novel pathogenic epitopes of myelin oligodendrocyte glycoprotein induce experimental autoimmune encephalomyelitis in C57BL/6 mice
Cecile Delarasse
Immunology, 140(4), 456-464 (2013)
Rong Chen et al.
Frontiers in molecular neuroscience, 13, 114-114 (2020-07-23)
Multiple sclerosis (MS) is an inflammatory autoimmune disease affecting the central nervous system (CNS) that currently does not have any effective treatment. Experimental autoimmune encephalomyelitis (EAE) is often employed as a model to mimic the clinical manifestations of MS, mainly
Pei-Xin Shen et al.
EBioMedicine, 64, 103227-103227 (2021-02-03)
Urolithin A (URA) is an intestinal microbiota metabolic product from ellagitannin-containing foods with multiple biological activities. However, its role in autoimmune diseases is largely unknown. Here, for first time, we demonstrate the therapeutic effect of URA in an experimental autoimmune
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