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M149

Sigma-Aldrich

甲硫替平 甲磺酸盐

≥98% (HPLC), solid

别名:

1-[10，11-二氢-8-（甲硫基）二苯并[b，f]硫平-10-基]-4-甲基哌嗪 甲磺酸盐, 甲替平 甲磺酸盐

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About This Item

线性分子式:
C20H24N2S2 · CH3SO3H
CAS号:
74611-28-2
分子量:
452.65
MDL號碼:
MFCD00153831
分類程式碼代碼:
12352200
PubChem物質ID:
24278104
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

solid

儲存條件

desiccated

顏色

white

溶解度

H2O: 13 mg/mL

SMILES 字串

CS(O)(=O)=O.CSc1ccc2Sc3ccccc3CC(N4CCN(C)CC4)c2c1

InChI

1S/C20H24N2S2.CH4O3S/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20;1-5(2,3)4/h3-8,14,18H,9-13H2,1-2H3;1H3,(H,2,3,4)

InChI 密鑰

CZMDZGZYKOGLJY-UHFFFAOYSA-N

基因資訊

human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR6(3362) , HTR7(3363)

一般說明

甲硫替平属于一类新的二苯并噻吩。甲硫替平具有精神抑制活性。

應用

甲硫替平甲磺酸盐已用于探索循环细胞与生态位之间的关系。它也已用于5-羟色胺（5-HT）和拮抗剂体内生物测定以及体内拮抗剂和脂多糖刺激。

生化／生理作用

甲硫替平甲磺酸盐是一种5-HT1、5-HT6、5-HT75-羟色胺受体拮抗剂，可阻断5-羟色胺自身受体。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
095M4737V
114M4719V
123M4719V
109K4612
106K47053

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P Schoeffter et al.
British journal of pharmacology, 117(6), 993-994 (1996-03-01)
Human uterine artery smooth muscle cells in culture were shown to express constitutively both 5-ht7 receptor mRNA and 5-ht7-like receptors functionally linked to cyclic AMP formation. 5-Carboxamidotryptamine (5-CT) and 5-HT enhanced forskolin-stimulated cyclic AMP accumulation in these cells, with pEC50
C Grånäs et al.
European journal of pharmacology, 380(2-3), 171-181 (1999-10-08)
Site-directed mutagenesis of the human 5-HT1B receptor was performed to investigate the role of the amino acid residues cysteine 326 and tryptophan 327 in transmembrane region VI and aspartic acid 352 in transmembrane region VII in ligand binding. Binding studies
Primary neuronal precursors in adult crayfish brain: replenishment from a non-neuronal source
Benton J L, et al.
BMC Neuroscience, 12(1), 53-53 (2011)
T Nilsson et al.
European journal of pharmacology, 372(1), 49-56 (1999-06-22)
5-Hydroxytryptamine (5-HT) can produce both vasoconstrictor and vasorelaxant effects in human coronary arteries and the response to 5-HT can be influenced by the presence of disease. The aim of the present study was to elucidate the 5-HT receptor subtypes responsible
A serotonin receptor (Cg5-HTR-1) mediating immune response in oyster Crassostrea gigas
Jia Y, et al.
Developmental and Comparative Immunology, 82, 83-93 (2018)
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