M0639

6α-甲基泼尼松龙

≥98%

• 别名: 11β,17α,21-三羟基-6α-甲基-1,4-孕甾二烯-3,20-二酮, 6α-甲基-11β,17α,21-三羟基-1,4-孕甾二烯-3,20-二酮, 甲基强的松龙, 甲基泼尼松龙
• 经验公式（希尔记法）: C₂₂H₃₀O₅
• CAS号: 83-43-2
• 分子量: 374.47
• Beilstein: 2340300
• EC號碼: 201-476-4
• MDL號碼: MFCD00010591
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24896564
• NACRES: NA.77

属性

• 生物源: synthetic
• 無菌: non-sterile
• 化驗: ≥98%
• 形狀: powder
• 溶解度: chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow
• 應用: cell analysis
• 運輸包裝: ambient
• 儲存溫度: room temp
• SMILES 字串: [H][C@@]12C[C@H](C)C3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
• InChI: 1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1
• InChI 密鑰: VHRSUDSXCMQTMA-PJHHCJLFSA-N
• 基因資訊: human ... NR3C1(2908) ; rat ... Nr3c1(24413)

说明

應用

6α-Methylprednisolone has been used:

• to stimulate RPMI 8226.1 cells in order to govern the expression of human interleukin-10 (IL-10) gene
• to induce depletion of CD14⁺ CD16⁺ monocytes
• to study its effect on behavioral and sensory afferent hypersensitivity

生化／生理作用

Methylprednisolone is a glucocorticoid having anti-inflammatory and immunosuppressive actions. It is useful in treating skin diseases, allergies, multiple sclerosis, asthma, rheumatic disorders, chronic obstructive pulmonary disease, croup and cancer.

包裝

Bottomless glass bottle. Contents are inside inserted fused cone.

安全信息

• 象形圖: GHS08
• 訊號詞: Danger
• 危險聲明: H360FD,H373
• 防範說明: P202 - P260 - P280 - P308 + P313 - P405 - P501
• 危險分類: Repr. 1B - STOT RE 2
• 標靶器官: Adrenal gland,Immune system
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 2
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)