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應用
Microsomes from Liver, Pooled has been used:
- in the glucuronidation kinetics assay to test the effects of herbal extracts on glucuronidation process
- as a human liver microsomes (HLM) matrix for testing metabolic stability of talazoparib using liquid chromatography-tandem mass spectrometry (LC–MS/MS)
- to study the metabolization of enantiomeric peptide D3
Microsomes from liver have been used in a study to assess differences in enzymatic activities between normal rat livers and from liver after partial hepatectomy. They have also been used in a study to investigate the carbon monoxide-binding pigment in liver microsomes.
生化／生理作用
肝微粒体是来源于肝细胞内质网的亚细胞颗粒。这些微粒体是药物代谢酶（包括细胞色素 P-450）的丰富来源。不同来源的微粒体池有助于研究外源代谢和药物相互作用。
N-glucuronidation of various 1-substituted imidazoles was found to occur in human liver microsomes.
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
The enzymatic composition of rat liver microsomes during liver regeneration.
von der DECKEN et al.
Experimental cell research, 19, 591-604 (1960-04-01)
The Carbon Monoxide-binding pigment of liver microsomes II. Solubilization, purification and properties.
Omura, T. and Sato, R.
Journal of Biochemistry, 239, 2379-2385 (1964)
THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.
T OMURA et al.
The Journal of biological chemistry, 239, 2370-2378 (1964-07-01)
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Tandutinib (MLN518 or CT 53518) (TND) is a novel, oral, small-molecule inhibitor of type III receptor tyrosine kinases utilized for the treatment of acute myeloid leukemia (AML). In silico prediction of hepatic drug metabolism for TND was determined using the
Ali S Abdelhameed et al.
Royal Society open science, 6(6), 190434-190434 (2019-07-18)
Spebrutinib (SBT) is a Bruton's tyrosine kinase inhibitor. SBT is currently in phase II and phase I clinical trials for the management of rheumatoid arthritis and chronic lymphocytic leukaemia, respectively. We developed and validated a liquid chromatography tandem mass spectrometry
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