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文件

L9668

Lidoflazine

Name: Lidoflazine
Brand: SIGMA

≥98% (HPLC), powder

别名:

4-[4,4-Bis(4-fluorophenyl)butyl]-N-(2,6-dimethylphenyl)-1-piperazineacetamide

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About This Item

经验公式（希尔记法）:

C₃₀H₃₅F₂N₃O

CAS号:

3416-26-0

分子量:

491.62

EC號碼:

222-312-8

MDL號碼:

MFCD00057353

分類程式碼代碼:

12352200

PubChem物質ID:

329817673

NACRES:

NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

white

溶解度

DMSO: ≥10 mg/mL

儲存溫度

2-8°C

SMILES 字串

Cc1cccc(C)c1NC(=O)CN2CCN(CCCC(c3ccc(F)cc3)c4ccc(F)cc4)CC2

InChI

1S/C30H35F2N3O/c1-22-5-3-6-23(2)30(22)33-29(36)21-35-19-17-34(18-20-35)16-4-7-28(24-8-12-26(31)13-9-24)25-10-14-27(32)15-11-25/h3,5-6,8-15,28H,4,7,16-21H2,1-2H3,(H,33,36)

InChI 密鑰

ZBIAKUMOEKILTF-UHFFFAOYSA-N

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生化／生理作用

Lidoflazine is an antianginal calcium channel blocker that carries a significant risk of QT interval prolongation and ventricular arrhythmia. It prolongs QT interval by blocking HERG channel. IC₅₀ < 0.1 μM

特點和優勢

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

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The cardioprotective effects of R 75231 and lidoflazine are not caused by adenosine A1 receptor activation.

G J Grover et al.

The Journal of pharmacology and experimental therapeutics, 268(1), 90-96 (1994-01-01)

The goal of this study was to determine the cardioprotective profile for the nucleoside transport inhibitor 2-(aminocarboxyl)-N-(4-amino-2,6-dichlorophenyl)-4-[5,5-bis(4- fluorophenyl)pentyl]-1-piperazinylacetamide trihydrochloride-2,5 hydrate (R 75231) in isolated rat hearts and whether its protective effects are caused by adenosine A1 activation. R 75231 increased

Blood pressure-lowering treatment for preventing recurrent stroke, major vascular events, and dementia in patients with a history of stroke or transient ischaemic attack.

Thomas P Zonneveld et al.

The Cochrane database of systematic reviews, 7, CD007858-CD007858 (2018-07-20)

Stroke is an important cause of death and disability worldwide. Since high blood pressure is an important risk factor for stroke and stroke recurrence, drugs that lower blood pressure might play an important role in secondary stroke prevention. To investigate

Central-to-peripheral arterial pressure gradient during cardiopulmonary bypass: relation to pre- and intra-operative data and effects of vasoactive agents.

S G De Hert et al.

Acta anaesthesiologica Scandinavica, 38(5), 479-485 (1994-07-01)

A significant central-to-peripheral arterial pressure gradient may exist during and after cardiopulmonary bypass (CPB). The etiology and mechanisms of this phenomenon remain controversial. We studied the pressure gradient between aorta, brachial artery and radial artery in 68 patients, scheduled for

Old age does not negate good cerebral outcome after cardiopulmonary resuscitation: analyses from the brain resuscitation clinical trials. The Brain Resuscitation Clinical Trial I and II Study Groups.

H J Rogove et al.

Critical care medicine, 23(1), 18-25 (1995-01-01)

To assess survival after cardiac arrest and to determine whether age is an independent determinant of late mortality or poor neurologic outcome. Analyses using results of Brain Resuscitation Clinical Trial I (1979 to 1984) and Brain Resuscitation Clinical Trial II

Effects of lidoflazine on left ventricular function in patients.

S G De Hert et al.

Journal of cardiothoracic and vascular anesthesia, 11(1), 42-48 (1997-02-01)

The present study evaluated the effects of the nucleoside transport inhibitor, lidoflazine, at a dose of 1 mg/kg, on left ventricular function. Patients were randomly assigned to receive either lidoflazine or saline in a double-blind manner. A university hospital. The

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