L5647

利多卡因 盐酸盐 一水合物

≥99% (HPLC), solid, Na⁺ channel blocker

• 别名: 2-二乙氨基-N-（2，6-二甲苯基）乙酰胺 盐酸盐 一水合物, 利多卡因 盐酸盐 一水合物, 赛洛卡因 盐酸盐 一水合物
• 经验公式（希尔记法）: C₁₄H₂₂N₂O · HCl · H₂O
• CAS号: 6108-05-0
• 分子量: 288.81
• EC號碼: 200-803-8
• MDL號碼: MFCD00150329
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24277718
• NACRES: NA.77

属性

• 产品名称: 利多卡因 盐酸盐 一水合物, solid
• 形狀: solid
• 顏色: white
• 溶解度: H₂O: soluble
• SMILES 字串: Cl[H].[H]O[H].CCN(CC)CC(=O)Nc1c(C)cccc1C
• InChI: 1S/C14H22N2O.ClH.H2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H;1H2
• InChI 密鑰: YECIFGHRMFEPJK-UHFFFAOYSA-N
• 基因資訊: human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

说明

一般說明

Lidocaine hydrochloride monohydrate is a commonly used as local anesthetic in topical applications and oral mucosal biopsies. It has a short anesthetic half-life.

應用

Lidocaine hydrochloride monohydrate has been used:

• in the preparation of drug composite for the controlled delivery in vitro, evaluated by drug release profile in ultra-high performance liquid chromatography (UPLC) and as a reference standard for fourier transform infrared spectroscopy (FT-IR).
• to record dose dependent response of sodium voltage (Nav1.7) channels in the injection-molded polymer device.
• For inhibition of glial cells in brain tissue samples.

生化／生理作用

Na⁺ 通道阻滞剂；IB 类抗心律失常药，在肠胃外给药后迅速吸收

Na⁺ 通道阻滞剂；IB 类抗心律失常药。

安全信息

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H301
• 防範說明: P301 + P310 + P330
• 危險分類: Acute Tox. 3 Oral
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Faceshields, Gloves