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L4897

Sigma-Aldrich

Luteinizing hormone releasing hormone salmon

≥97% (HPLC)

别名:

GnRH, Gonadoliberin, Gonadotropin releasing hormone, LH-RH

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About This Item

经验公式（希尔记法）:
C60H73N15O13
CAS号:
86073-88-3
分子量:
1212.31
MDL號碼:
MFCD00133497
分類程式碼代碼:
51111800
PubChem物質ID:
24896381
NACRES:
NA.32

品質等級

200

化驗

≥97% (HPLC)

UniProt登錄號

P55248
P01148
P07490
P13562
P30968
P30969
Q01776

儲存溫度

−20°C

SMILES 字串

CC(C)CC(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)C(Cc3ccc(O)cc3)NC(=O)C(CO)NC(=O)C(Cc4c[nH]c5ccccc45)NC(=O)C(Cc6cnc[nH]6)NC(=O)C7CCC(=O)N7)C(=O)N8CCCC8C(=O)NCC(N)=O

InChI

1S/C60H73N15O13/c1-32(2)20-47(60(88)75-19-7-12-49(75)59(87)65-28-50(61)78)73-55(83)44(22-34-25-63-40-10-5-3-8-38(34)40)69-52(80)29-66-53(81)43(21-33-13-15-37(77)16-14-33)70-58(86)48(30-76)74-56(84)45(23-35-26-64-41-11-6-4-9-39(35)41)71-57(85)46(24-36-27-62-31-67-36)72-54(82)42-17-18-51(79)68-42/h3-6,8-11,13-16,25-27,31-32,42-49,63-64,76-77H,7,12,17-24,28-30H2,1-2H3,(H2,61,78)(H,62,67)(H,65,87)(H,66,81)(H,68,79)(H,69,80)(H,70,86)(H,71,85)(H,72,82)(H,73,83)(H,74,84)

InChI 密鑰

NMJREATYWWNIKX-UHFFFAOYSA-N

基因資訊

human ... GNRH1(2796) , GNRHR(2798)
mouse ... GNRH1(14714) , GNRHR(14715)
rat ... GNRH1(25194) , GNRHR(81668)

Amino Acid Sequence

Glp-His-Trp-Ser-Tyr-Gly-Trp-Leu-Pro-Gly-NH2

應用

Luteinizing hormone releasing hormone (salmon) has been used to study the effect of LHRH (luteinizing hormone releasing hormone) in the brain of Podarcis sicula sicula (male) during reproduction. It has been used to study the hormonal regulation of PACAP (pituitary adenylate cyclase-activating polypeptide) and its receptor, PAC1 (adenylate cyclase activating polypeptide 1 (pituitary) receptor type I).

生化／生理作用

Hypothalamic peptide that stimulates release of gonadotrophins from anterior pituitary, thus regulating reproductive functions.

其他說明

Lyophilized from 0.5% acetic acid

象形圖

Health hazard
GHS08

訊號詞

Danger

危險聲明

H360

防範說明

P201 - P308 + P313

危險分類

Repr. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

分析证书(COA)

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A Gobbetti et al.
Journal of reproduction and fertility, 101(3), 523-529 (1994-08-01)
The release of PGF2 alpha and PGE2, progesterone, androgens and oestradiol in vitro, and the aromatase activity in the brain of the male lizard Podarcis sicula sicula during three different phases of the reproductive period were evaluated. In addition, the
Weiming Zheng et al.
Reproductive sciences (Thousand Oaks, Calif.), 21(1), 41-51 (2013-05-22)
Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors are expressed in the hypothalamus, the gonadotrope cells of the anterior pituitary gland, and the gonads, forming an autocrine-paracrine system in these tissues. Within the pituitary, PACAP functions either alone or synergistically
Sameer Sharma et al.
Vaccine, 32(43), 5555-5563 (2014-08-19)
Two gonadotrophin releasing hormone (GnRH) constructs prepared by either chemical conjugation to keyhole limpet hemocyanin (GnRH-KLH) or as an expressed recombinant fusion protein (Multimer) were evaluated with or without adjuvants (immunostimulating complexes, ISCOMs, or cytosine-phosphate-guanosine oligodeoxynucleotides, CpG ODNs). After subcutaneous
Kazue Nagasawa et al.
PloS one, 10(6), e0129571-e0129571 (2015-06-02)
Existing research on the role of gonadotropin-releasing hormone (GnRH) in bivalve reproduction is inadequate, even though a few bivalve GnRH orthologs have been cloned. The objective of this paper was to elucidate the in vivo effect of GnRH administration in
Shel-Hwa Yeo et al.
Neuroendocrinology, 100(2-3), 191-197 (2014-10-11)
Kisspeptin-Gpr54 signaling is critical for regulating the activity of gonadotropin-releasing hormone (GnRH) neurons in mammals. Previous studies have shown that the negative feedback mechanism is disrupted in global Gpr54-null mutants. The present investigation aimed to determine (1) if a lack
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