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K3761

Sigma-Aldrich

KT 5720

≥98% (HPLC), powder

别名:

(9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid hexyl ester

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About This Item

经验公式（希尔记法）:
C32H31N3O5
CAS号:
108068-98-0
分子量:
537.61
MDL號碼:
MFCD00132118
分類程式碼代碼:
51111800
PubChem物質ID:
24896235
NACRES:
NA.77

生物源

microbial

品質等級

200

化驗

≥98% (HPLC)

形狀

powder

顏色

white to faint yellow

溶解度

methanol: 5 mg/mL

運輸包裝

wet ice

儲存溫度

−20°C

SMILES 字串

CCCCCCOC([C@@]1(O)C[C@@]2([H])N3C(C=CC=C4)=C4C5=C3C6=C(C(C=CC=C7)=C7N6[C@]1(C)O2)C8=C5C(NC8)=O)=O

InChI

1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36)/t23-,31+,32-/m0/s1

InChI 密鑰

ZHEHVZXPFVXKEY-IKZDWWSZSA-N

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應用

KT 5720 has been used as a chemical inhibitor of cell signaling pathway. It has also been used as a protein kinase A (PKA) inhibitor to study its effect on the nuclear import of CRTC1 in α-MSH-activated B16-F0 cells and on COX-2 stimulation of tumor-associated Vascular endothelial growth factor (VEGF) expression.

生化／生理作用

Specific, cell-permeable inhibitor of protein kinase A (PKA). No significant effect on protein kinase C (PKC), protein kinase G (PKG) or myosin light chain kinase (MLCK).

特點和優勢

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Elizabeth A Townsend et al.
American journal of physiology. Lung cellular and molecular physiology, 303(10), L923-L928 (2012-09-25)
Clinically observed differences in airway reactivity and asthma exacerbations in women at different life stages suggest a role for sex steroids in modulating airway function although their targets and mechanisms of action are still being explored. We have previously shown
Nesfatin-1 induces the phosphorylation levels of cAMP response element-binding protein for intracellular signaling in a neural cell line
Ishida E, et al.
PLoS ONE, 7(12), e50918-e50918 (2012)
Swidbert R Ott et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(7), E381-E387 (2011-12-21)
The mechanisms that integrate genetic and environmental information to coordinate the expression of complex phenotypes are little understood. We investigated the role of two protein kinases (PKs) in the population density-dependent transition to gregarious behavior that underlies swarm formation in
Yi-hung CHEN et al.
Acta pharmacologica Sinica, 31(12), 1553-1563 (2010-11-03)
to investigate the effects of 2'-hydroxy-4'-methoxyacetophenone (paeonol) on the electrophysiological behavior of a central neuron (right parietal 4; RP4) of the giant African snail (Achatina fulica Ferussac). intracellular recordings and the two-electrode voltage clamp method were used to study the
Elizabeth M Forbes et al.
Neuron, 74(3), 490-503 (2012-05-15)
Correct guidance of axons to their targets depends on an intricate network of signaling molecules in the growth cone. Calcium and cAMP are two key regulators of whether axons are attracted or repelled by molecular gradients, but how these molecules
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