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生物源
synthetic (organic)
品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white
溶解度
DMSO: 1 mg/mL
H2O: soluble
儲存溫度
2-8°C
SMILES 字串
OP(O)(O)=O.COc1ccc(cc1)S(=O)(=O)N(CCO)c2ccccc2CN(C)C\C=C\c3ccc(Cl)cc3
InChI
1S/C26H29ClN2O4S.H3O4P/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25;1-5(2,3)4/h3-16,30H,17-20H2,1-2H3;(H3,1,2,3,4)/b6-5+;
InChI 密鑰
NNKJTPOXLIILMB-IPZCTEOASA-N
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應用
KN-93已用于以下情形:
- 作为抑制剂,阻挡αCaMKII (Ca2+/钙调蛋白依赖性蛋白激酶IIα)
- 作为CaMKII抑制剂,用于预处理海马脑片
- 在实验中处理细胞,修改细胞骨架(CSK)结构和功能
生化/生理作用
KN-93是一种选择性Ca2+/钙调蛋白依赖性蛋白激酶II抑制剂,它参与调节平滑肌收缩。。KN-93预处理可抑制CaM激酶II活化(IC50 ~1 μM)。KN-93可抑制组胺诱导的强直力维持,而在整个时间进程中早期力量发展和MLC20磷酸化反应未受影响。KN-93抑制了KCl刺激的力量发展和维持。KN-93也能抑制KCl诱导的MLC20磷酸化快速增加,而稳态MLC20磷酸化反应不受影响。相反,佛波醇12,13-二丁酸酯(PDBu)不能激活CaM激酶II,而PDBu刺激的力量发展不受KN-93影响。因此,KN-93可能靶向生理刺激诱导的力量维持所必需的阶段,这表明CaM激酶II可在调节动脉平滑肌的强直收缩反应中发挥作用。蛋白激酶C的药理活性不经过KN-93敏感阶段。
注意
光敏性
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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