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化驗
≥98% (HPLC)
形狀
powder
光學活性
[α]/D -65 to -75°, c = 1.0 in methanol
顏色
white to beige
溶解度
H2O: 2 mg/mL, clear
儲存溫度
room temp
InChI
1S/C17H26N4O.ClH/c1-2-6-16-14(5-1)7-8-15(22-16)13-18-9-3-10-19-17-20-11-4-12-21-17;/h1-2,5-6,15,18H,3-4,7-13H2,(H2,19,20,21);1H/t15-;/m1./s1
InChI 密鑰
BHFNHKKGGQTOBO-XFULWGLBSA-N
生化／生理作用
Alniditan is a potent and selective serotonin 5-HT1B/5-HT1D receptor agonist that exhibits antimigraine effects.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
A S Lesage et al.
British journal of pharmacology, 123(8), 1655-1665 (1998-05-30)
1. Alniditan, a novel migraine abortive agent, is a potent 5-HT1B/5-HT1D receptor agonist of nM affinity. We compared the agonistic properties of alniditan, sumatriptan and dihydroergotamine on the cloned human 5-HT1B receptor expressed at 200 fmol mg(-1) protein (Bmax) in
Pankaj Bhalla et al.
European journal of pharmacology, 436(1-2), 23-33 (2002-02-09)
Using a combination of reverse transcription polymerase chain reaction (RT-PCR) and inverse-PCR techniques, we amplified, cloned and sequenced a full-length porcine 5-hydroxytryptamine 1F (5-ht(1F)) receptor complementary DNA (cDNA) derived from porcine trigeminal ganglion. Sequence analysis revealed 1101 base pairs (bp)
J E Leysen et al.
Molecular pharmacology, 50(6), 1567-1580 (1996-12-01)
Alniditan is a new migraine-abortive agent. It is a benzopyran derivative and therefore structurally unrelated to sumatriptan and other indole-derivatives and to ergoline derivatives. The action of sumatriptan is thought to be mediated by 5-hydroxytryptamine (5-HT)1D-type receptors. We investigated the
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