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Merck
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文件

I9759

Sigma-Aldrich

L-异亮氨酰-L-脯氨酰-L-异亮氨酸

≥97% (HPLC)

别名:

抑二肽素 A

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About This Item

经验公式（希尔记法）:
C17H31N3O4
CAS号:
90614-48-5
分子量:
341.45
MDL號碼:
MFCD00038707
分類程式碼代碼:
51111800
PubChem物質ID:
24896160
NACRES:
NA.77

化驗

≥97% (HPLC)

形狀

powder

溶解度

water: 1 mg/mL, clear, colorless

儲存溫度

−20°C

SMILES 字串

CCC(C)C(N)C(=O)N1CCCC1C(=O)NC(C(C)CC)C(O)=O

InChI

1S/C17H31N3O4/c1-5-10(3)13(18)16(22)20-9-7-8-12(20)15(21)19-14(17(23)24)11(4)6-2/h10-14H,5-9,18H2,1-4H3,(H,19,21)(H,23,24)

InChI 密鑰

JNTMAZFVYNDPLB-UHFFFAOYSA-N

Amino Acid Sequence

Ile-Pro-Ile

應用

Ile-Pro-Ile 已被用作采血补充剂，用于测定激素 ，另外还用于稳定岛细胞培养物中的类胰升糖素肽1（GLP-1）。它还被用于抑制血清采集后促性腺激素抑制激素（GnIH）的分解。

生化／生理作用

二肽基肽酶 IV 的抑制剂。抑制 HIV-1 或 HIV-2 进入 T 淋巴母细胞样和单核细胞样细胞系。

特點和優勢

该化合物是受体分类及信号转导手册上神经肽酶页面上的特色化合物。想要浏览手册的其他页面， 请单击此处。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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Bile acids (BA) are pleiotropic hormones affecting glucose and lipid metabolism. The physiochemical properties of different BA species affect their enterohepatic dynamics and their affinity for bile acid receptors. The BA pool composition is altered in patients with type 2
Carlos García-Aparicio et al.
Journal of medicinal chemistry, 49(17), 5339-5351 (2006-08-18)
Here we describe a novel type of enzyme-based prodrug approach in which a dipeptide moiety is linked to a nonpeptidic therapeutic drug through an amide bond which is specifically cleaved by the dipeptidyl-peptidase IV (DPP IV/CD26) enzyme activity present in
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Diabetes care, 42(8), 1446-1453 (2019-06-10)
Roux-en-Y gastric bypass (RYGB) augments postprandial secretion of glucagon-like peptide 1 (GLP-1), oxyntomodulin (OXM), and peptide YY (PYY). Subcutaneous infusion of these hormones ("GOP"), mimicking postprandial levels, reduces energy intake. Our objective was to study the effects of GOP on
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