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Merck

I8010

Sigma-Aldrich

Anti-Human Polyvalent Immunoglobulins (G,A,M) antibody produced in rabbit

whole antiserum

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.46

生物源

rabbit

品質等級

共軛

unconjugated

抗體表格

whole antiserum

抗體產品種類

secondary antibodies

無性繁殖

polyclonal

包含

15 mM sodium azide

技術

immunoelectrophoresis: suitable

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

一般說明

Immunoglobulin G (IgG) belongs to the immunoglobulin family and is a widely expressed serum antibody. IgG is usually found as a monomer. IgG antibody subtype is the most abundant of serum immunoglobulins of the immune system. About 70 percent of the total immunoglobulin consists of IgG. Immunoglobulin M (IgM ) is a high molecular weight protein that has five or six subunits. It is the first immunoglobulin produced by neonates.

應用

Anti-Human Polyvalent Immunoglobulins (G,A,M) antibody produced in rabbit has been used in enzyme-linked immunosorbent assay (ELISA) and sandwich ELISA.
Anti-Human Polyvalent Immunoglobulins (G,A,M) antibody produced in rabbit was used in sandwich ELISA as a standard.

生化/生理作用

IgG antibody subtype is the most abundant of serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defence of the neonate against infections. IgA antibody is secretory antibody and is present abundantly in mucous linings of gastrointestinal, respiratory and genitourinary tracts, tears and saliva. IgM antibodies are present as pentamers in the serum and are produced in response to antigens.
Immunoglobulin M (IgM) acts as an antigen specific part of the B cell antigen receptor on the surface of B lymphocytes that are not stimulated, in its monomeric form. Polymeric IgM molecules also serve as important activators of the classical complement cascade. IgM is essential in agglutination and cytolytic reactions. Immunoglobulin G (IgG) participates in hypersensitivity type II and type III.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

nwg

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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The severe combined immunodeficient-human peripheral blood stem cell (SCID-huPBSC) mouse: a xenotransplant model for huPBSC-initiated hematopoiesis
Goan SR, et al.
Blood, 86(1), 89-100 (1995)
Molecular Genetics of Immunoglobulin, 17, 575-586 (1987)
The Immunoglobulins: Structure and Function, 1-26 (1998)
C G Bridges et al.
Antimicrobial agents and chemotherapy, 40(5), 1072-1077 (1996-05-01)
The novel acyclonucleotide derivative of guanine, 9-[2-methylidene-3-(phosphonomethoxy)propyl] guanine (MDL 74,968), had antiviral activity comparable to those of 9-(2-phosphonomethoxyethyl) adenine (PMEA) and 2',3'-dideoxyinosine against laboratory strains of both human immunodeficiency virus (HIV) types 1 and 2 cultured in MT-4 cells and
MDL 74,968, a new acyclonucleotide analog: activity against human immunodeficiency virus in vitro and in the hu-PBL-SCID. beige mouse model of infection.
Bridges CG, et al.
Antimicrobial Agents and Chemotherapy, 40(5), 1072-1077 (1996)

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