I7160

IMS2186

≥98% (HPLC), solid

• 别名: 3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one
• 经验公式（希尔记法）: C₁₈H₁₆O₄
• CAS号: 1031206-36-6
• 分子量: 296.32
• MDL號碼: MFCD12912419
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329815315
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 儲存條件: desiccated
• 顏色: white to off-white
• 溶解度: DMSO: >20 mg/mL
• 儲存溫度: room temp
• SMILES 字串: COc1ccc(cc1O)\C=C2/COc3ccc(C)cc3C2=O
• InChI: 1S/C18H16O4/c1-11-3-5-16-14(7-11)18(20)13(10-22-16)8-12-4-6-17(21-2)15(19)9-12/h3-9,19H,10H2,1-2H3/b13-8+
• InChI 密鑰: BZCADTHMZLYKAR-MDWZMJQESA-N

说明

生化／生理作用

IMS2186 is an anti-proliferative and anti-angiogenic agent. Apparently IMS2186 blocks the cell cycle at G2 and inhibits the production of PGE2/TNF-α. IMS2186 inhibits cell growth in vitro in tumor cells, non-transformed fibroblasts, and retinal pigment epithelial cells. IMS2186 inhibits angiogenesis (IC₅₀ = 0.1 μM) and cell migration. Intraocular injection of IMS2186 could be a long-lasting effective treatment for CNV (choroidal neovascularization) in AMD (age-related macular degeneration) with a reduction in scarring and related visual loss.

安全信息

• 象形圖: GHS09
• 訊號詞: Warning
• 危險聲明: H410
• 防範說明: P273 - P391 - P501
• 危險分類: Aquatic Acute 1 - Aquatic Chronic 1
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves