I7016
H-7 dihydrochloride
≥98% (HPLC)
别名:
1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride, Isoquinoline-5-sulfonic 2-methyl-1-piperazide dihydrochloride
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所有图片(2)
About This Item
经验公式（希尔记法）:
C14H17N3O2S · 2HCl
CAS号:
分子量:
364.29
Beilstein:
5840763
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
化驗
≥98% (HPLC)
形狀
powder
溶解度
H2O: 20 mg/mL
儲存溫度
2-8°C
SMILES 字串
Cl.Cl.CC1CNCCN1S(=O)(=O)c2cccc3cnccc23
InChI
1S/C14H17N3O2S.2ClH/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14;;/h2-6,10-11,16H,7-9H2,1H3;2*1H
InChI 密鑰
OARGPFMFRLLKPF-UHFFFAOYSA-N
基因資訊
human ... PRKCA(5578) , PRKCB(5579) , PRKCD(5580) , PRKCE(5581) , PRKCG(5582) , PRKCH(5583) , PRKCI(5584)
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一般說明
H-7 dihydrochloride blocks human immunodeficiency virus (HIV-1) replication in MOLT-4 (clone No. 8) cell line. It increases the secretion of interleukin 1β (IL-1β).
應用
H-7 dihydrochloride has been used to study H-7-induced inhibition of contractility in rat embryo fibroblasts (REF52) cells and acts as a kinase inhibitor.
生化／生理作用
Inhibitor of cyclic nucleotide dependent protein kinase (PKA) and protein kinase C.
注意
Light sensitive
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
A new dimension in retrograde flow: centripetal movement of engulfed particles
Caspi A, et al.
Biophysical Journal, 81(4), 1990-2000 (2001)
Mechanism of inhibitory effect of glycyrrhizin on replication of human immunodeficiency virus (HIV)
Ito M, et al.
Antiviral Research, 10(6), 289-298 (1988)
Molecular diversity of cell-matrix adhesions
Zamir E, et al.
Journal of Cell Science, 112(11), 1655-1669 (1999)
Endotoxin in Health and Disease, 289-298 (1999)
Christopher J Groten et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(6), 2747-2765 (2015-02-13)
It is unknown whether neurons can dynamically control the capacity for secretion by promptly changing the number of plasma membrane voltage-gated Ca(2+) channels. To address this, we studied peptide release from the bag cell neurons of Aplysia californica, which initiate
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