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Merck

I6256

Sigma-Aldrich

2-亚氨基硫烷 盐酸盐

≥98% (TLC), powder

别名:

2-亚氨基硫杂环戊烷 盐酸盐, 2-亚氨基硫烷盐酸盐 盐酸盐, 2IT, Traut 试剂

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About This Item

经验公式(希尔记法):
C4H7NS · HCl
CAS号:
分子量:
137.63
Beilstein:
3620079
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.21
化驗:
≥98% (TLC)
形狀:
powder
溶解度:
H2O: 100 mg/mL

品質等級

化驗

≥98% (TLC)

形狀

powder

雜質

≤5% Free sulfhydryl groups

mp

198-201 °C (lit.)

溶解度

H2O: 100 mg/mL

官能基

thioether

儲存溫度

2-8°C

SMILES 字串

N=C1SCCC1.Cl

InChI

1S/C4H7NS.ClH/c5-4-2-1-3-6-4;/h5H,1-3H2;1H

InChI 密鑰

ATGUDZODTABURZ-UHFFFAOYSA-N

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一般說明

2-氨基硫代乙烷盐酸盐(2-IT.HCl),一种蛋白质修饰试剂,通常用于将硫醇基团连接到蛋白质和肽上。用 2-IT 修饰的毛发角蛋白纤维的拉曼光谱分析。HCl 显示出新的二硫化物基团的形成。

應用

2-硫代乙烯基盐酸盐已用于合成硫醇化 PEG(聚(乙二醇))。它可用于合成 PLA-SH(聚乙二醇-硫醇)和 PLA-PEG-SH(聚乙二醇-聚乳酸-硫醇)。
伯胺的硫醇化试剂。在 pH 7-10 下,通过脒键反应,得到游离巯基。 可用于制备二硫化物和/或硫醚连接的缀合物。

其他說明

注意:脒键具有初始伯胺的正电荷。包含五个原子的连接臂。

象形圖

Skull and crossbones

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 3 Oral

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Akio Kuzuhara
Biopolymers, 79(4), 173-184 (2005-09-08)
For the purpose of investigating in detail the influence of chemical modification using 2-iminothiolane hydrochloride (2-IT) on keratin fibers, the structure of cross-sections at various depths of white human hair, treated with 2-IT and then oxidized, was directly analyzed without
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Scientific reports, 9(1), 9563-9563 (2019-07-04)
This study aims to prepare, characterize and evaluate the pharmacokinetics of liposomal donepezil HCl (LDH) dispersed into thiolated chitosan hydrogel (TCH) in rabbits. Various hydrogels including TCH were prepared, and after characterization, TCH was selected for subsequent evaluations, due to
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R R Traut et al.
Biochemistry, 12(17), 3266-3273 (1973-08-14)
Hafizah Mahmud et al.
International journal of molecular sciences, 19(3) (2018-03-03)
We recently have established a successful xenograft model of human glioblastoma cells by enriching hyaluronic acid-dependent spheroid-forming populations termed U251MG-P1 cells from U251MG cells. Since U251MG-P1 cells have been confirmed to express CD44 along with principal stemness marker genes, OCT3/4
Alexander Ewe et al.
Nanomedicine : nanotechnology, biology, and medicine, 13(1), 209-218 (2016-08-25)
Therapeutic applications of RNA interference (RNAi) require efficient siRNA delivery strategies in vivo. Combining lipid-based carriers with polymeric nanoparticles offers the favorable properties of both systems. This is the first study to explore polyethylenimine-based lipopolyplexes comprising a low-molecular weight PEI

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