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一般說明
肌醇(MI,myo-肌醇)是一种糖样分子,主要存在于人脑的神经胶质细胞中。它是C6糖醇的立体异构体,属于肌醇家族的一员。可作为三磷酸肌醇的前体,也可充当胞内第二信使。Myo-肌醇调节多种激素水平,如促甲状腺激素、促卵泡激素(FSH)和胰岛素。Myo-肌醇和d-chiro-肌醇(肌醇的另一种立体异构体)以不同方式平衡胰岛素抵抗(IR)有关的代谢异常。
應用
肌醇已用于:
- 作为气-液相色谱法(GC)单糖分析的标准品
- 作为无R海马培养基的组成部分,用于腹腔巨噬细胞(PMΦ)的培养,以研究细胞糖酵解代谢
- 作为SOFaaci培养基的补充,用于延长体外胚胎生长
- 作为α最低必需培养基(αMEM)完全培养基的组分,用于培养自然杀伤(NK)细胞系
生化/生理作用
肌醇(MI)作为渗透剂,是膜磷酸肌醇和磷脂的重要前体。它有助于形成细胞膜和髓鞘片结构。在阿尔茨海默症、脑胶质瘤病和脑肿瘤等各种脑部疾病中观察到肌醇(MI)浓度增加。
膜磷脂、糖基化磷脂酰肌醇锚定蛋白、磷酸肌醇酯第二信使的成分,其中锚定蛋白可将糖蛋白锚定到细胞膜上。
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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