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Merck

I5125

Sigma-Aldrich

肌醇 -肌醇

≥99% (GC), powder, precursor of membrane phospho-inositides and phospholipid

别名:

meso-肌醇, 环己六醇, 肌糖

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About This Item

经验公式(希尔记法):
C6H12O6
CAS号:
分子量:
180.16
Beilstein:
1907329
EC號碼:
MDL號碼:
分類程式碼代碼:
12352207
PubChem物質ID:
NACRES:
NA.77

product name

肌醇 -肌醇, ≥99%

蒸汽密度

6.2 (vs air)

品質等級

化驗

≥99%

mp

222-227 °C (lit.)

溶解度

H2O: 50 mg/mL

SMILES 字串

O[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6-

InChI 密鑰

CDAISMWEOUEBRE-GPIVLXJGSA-N

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一般說明

肌醇(MI,myo-肌醇)是一种糖样分子,主要存在于人脑的神经胶质细胞中。它是C6糖醇的立体异构体,属于肌醇家族的一员。可作为三磷酸肌醇的前体,也可充当胞内第二信使。Myo-肌醇调节多种激素水平,如促甲状腺激素、促卵泡激素(FSH)和胰岛素。Myo-肌醇和d-chiro-肌醇(肌醇的另一种立体异构体)以不同方式平衡胰岛素抵抗(IR)有关的代谢异常。

應用

肌醇已用于:
  • 作为气-液相色谱法(GC)单糖分析的标准品
  • 作为无R海马培养基的组成部分,用于腹腔巨噬细胞(PMΦ)的培养,以研究细胞糖酵解代谢
  • 作为SOFaaci培养基的补充,用于延长体外胚胎生长
  • 作为α最低必需培养基(αMEM)完全培养基的组分,用于培养自然杀伤(NK)细胞系

生化/生理作用

肌醇(MI)作为渗透剂,是膜磷酸肌醇和磷脂的重要前体。它有助于形成细胞膜和髓鞘片结构。在阿尔茨海默症、脑胶质瘤病和脑肿瘤等各种脑部疾病中观察到肌醇(MI)浓度增加。
膜磷脂、糖基化磷脂酰肌醇锚定蛋白、磷酸肌醇酯第二信使的成分,其中锚定蛋白可将糖蛋白锚定到细胞膜上。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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