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生物源
mouse
品質等級
重組細胞
expressed in E. coli
化驗
>97% (SDS-PAGE)
形狀
lyophilized powder
效力
0.01-1.50 ng/mL EC50
分子量
~18 kDa
包裝
pkg of 5 μg
技術
cell culture | mammalian: suitable
雜質
endotoxin, tested
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
基因資訊
mouse ... Il10(16153)
相关类别
應用
来自小鼠的白介素-10已被用作ELISA（酶联免疫吸附测定）细胞因子测定的标准品。
生化／生理作用
白介素-10是淋巴和髓样细胞功能的重要调节剂。IL-10可以阻断细胞因子合成的激活和巨噬细胞的几种辅助功能。人和小鼠IL-10具有73%的序列同源性。然而，人IL-10同时作用于人和小鼠靶细胞，而小鼠IL-10具有物种特异性活性。在小鼠中，IL-10的细胞来源包括Th2细胞，活化的胎儿胸腺细胞，巨噬细胞，角质形成细胞，LY-1+ （CD5+）和正常B细胞。在人类中，IL-10的细胞来源包括CD4+T细胞和T细胞克隆，胸腺细胞，B细胞，B细胞淋巴瘤，巨噬细胞，肥大细胞系和角质形成细胞。IL-10刺激干细胞，肥大细胞和胸腺细胞的生长。IL-10增强细胞毒性T细胞发育并共同刺激B细胞分化和Ig分泌。 IL-10通过诱导血管生成或血管抑制因子的细胞类型依赖性表达来调节血管生成。
白介素-10调节淋巴和髓样细胞功能它阻断细胞因子合成的激活和巨噬细胞的几种辅助功能。IL-10增强细胞毒性T细胞发育并共同刺激B细胞分化和Ig分泌。IL-10通过诱导血管生成或血管抑制因子的细胞类型依赖性表达来调节血管生成。
外觀
从PBS中经0.2 μm过滤的溶液pH 7.4中冻干，每1μg含50 μg BSA作为载体蛋白
分析報告
在使用MC/9细胞的细胞增殖测定中测定IL-10的生物活性。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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The Interleukins comprise a disparate group of cytokines and growth factors that are produced by and released from leukocytes. Interleukin-1β (1L-1β) is released primarily from stimulated macrophages and monocytes and plays a key role in inflammatory and immune responses and may induce anti-tumor immunity.
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