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生物源
mouse
品質等級
重組細胞
expressed in E. coli
化驗
≥97% (SDS-PAGE)
形狀
lyophilized powder
效力
1-10 ng/mL EC50
分子量
11.5 kDa (predicted; 9 kDa under reducing conditions)
包裝
pkg of 5 μg
技術
cell culture | mammalian: suitable
雜質
endotoxin, tested
UniProt登錄號
儲存溫度
−20°C
基因資訊
mouse ... Il13(16163)
相关类别
生化／生理作用
白细胞介素-13是由小鼠和人类中活化的Th2细胞产生的多效性细胞因子。IL-13主要分泌为132个氨基酸的未糖基化蛋白，分子量为10,000道尔顿。对小鼠IL-13基因的4.3 kb DNA片段进行测序，并以映射11号染色体的单拷贝形式出现。在人类中，IL-13基因的4.6 kb DNA片段以单拷贝形式出现，并映射到5号染色体。IL-13诱导B细胞增殖，还诱导IgE转换。使用人红白血病细胞系TF-1在培养物中检测人和小鼠IL-13产品的增殖活性。
外觀
从含有50 μg牛血清白蛋白（BSA）/1 μg细胞因子的磷酸盐缓冲盐水（PBS）（pH值7.4）的0.2 μm过滤溶液中冻干
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
Luke Hatchwell et al.
Thorax, 70(9), 854-861 (2015-06-26)
Asthma exacerbations represent a significant disease burden and are commonly caused by rhinovirus (RV), which is sensed by Toll-like receptors (TLR) such as TLR7. Some asthmatics have impaired interferon (IFN) responses to RV, but the underlying mechanisms of this clinically
Kihyuk Shin et al.
Clinical and experimental medicine, 15(3), 233-244 (2014-06-14)
The leukotrienes (LTs) enhance allergen- and interleukin (IL)-13-dependent allergic lung inflammatory disease. However, the precise requirement of LTs and the mechanism by which they elicit allergic lung responses remain uncertain. To clarify the involvement of LTs in respiratory allergen- and
Gui Yang et al.
The Journal of biological chemistry, 290(20), 12858-12867 (2015-04-04)
Restoration of the antigen (Ag)-specific immune tolerance in an allergic environment is refractory. B cells are involved in immune regulation. Whether B cells facilitate the generation of Ag-specific immune tolerance in an allergic environment requires further investigation. This paper aims
C Abrial et al.
British journal of pharmacology, 172(17), 4319-4330 (2015-06-05)
15-Lipoxygenase (15-LOX) activity is associated with inflammation and immune regulation. The objectives of the present study were to investigate the expression of 15-LOX-1 and 15-LOX-2 and evaluate the enzymes' roles in the polarization of human lung macrophages (LMs) in response
Haixia Zhao et al.
Toxicology and applied pharmacology, 279(3), 311-321 (2014-07-16)
M2 macrophage polarization is implicated in colorectal cancer development. Isoliquiritigenin (ISL), a flavonoid from licorice, has been reported to prevent azoxymethane (AOM) induced colon carcinogenesis in animal models. Here, in a mouse model of colitis-associated tumorigenesis induced by AOM/dextran sodium
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The Interleukins comprise a disparate group of cytokines and growth factors that are produced by and released from leukocytes. Interleukin-1β (1L-1β) is released primarily from stimulated macrophages and monocytes and plays a key role in inflammatory and immune responses and may induce anti-tumor immunity.
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