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Merck

I2386

Sigma-Aldrich

抗 人 IgM(μ-链特异性) 山羊抗

affinity isolated antibody, buffered aqueous solution

别名:

Anti-IgM produced in Goat, Goat Anti-Human IgM, IgM Detection Antibody

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.46

生物源

goat

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

secondary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

技術

indirect ELISA: 1:20,000-1:40,000

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

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一般說明

IgM抗体在血清中以五聚体的形式存在,为响应抗原而产生。

應用

山羊抗人IgM(μ链特异性)抗体可用于酶联免疫吸附测定(ELISA)。

生化/生理作用

免疫球蛋白M(IgM)抗体是针对抗原的反应而产生的主要抗体。它们以低亲和力结合,但是对多种抗原表现出广泛的特异性。IgM占成人免疫球蛋白的15%。由于多种原因,IgM对于胎儿和新生儿的宿主防御很重要。IgM分子高效地激活补体经典途径。其五聚体结构有助于实现与多价配体的结合。IgM在清除血清中的入侵微生物方面具有重要作用。

外觀

溶于含有15 mM叠氮化钠的0.01 M磷酸盐缓冲液(pH 7.4)

免責聲明

除非我们的目录或随附于产品的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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Juha Ollila et al.
Molecular immunology, 44(14), 3537-3551 (2007-05-09)
B-cell development into antibody producing cells is a complex process that relies on the tightly controlled production of hundreds of genes and proteins. A B-cell is activated through the B-cell receptor (BCR) and this activation is modified by different co-stimulatory
Avery's Diseases of the Newborn E-Book, 460-460 (2011)
Anti-protein immunoglobulin M responses to pneumococcus are not associated with aging
German EL, et al.
Pneumonia (Nathan Qld.), 10(1), 5-5 (2018)
X Guo et al.
Oncogene, 36(29), 4224-4232 (2017-04-04)
Diffuse large B-cell lymphoma (DLBCL) has been categorized into two molecular subtypes that have prognostic significance, namely germinal center B-cell like (GCB) and activated B-cell like (ABC). Although ABC-DLBCL has been associated with NF-κB activation, the relationships between activation of
J Ollila et al.
Genes and immunity, 4(5), 343-350 (2003-07-09)
The development of adaptive immunity and responses to foreign molecules and organisms relies on the highly regulated production of hundreds of proteins. B-cell maturation, from committed progenitors to terminally differentiated plasma cells, is a multistep process that requires the ordered

商品

Antibody-based serology tests are useful in identifying subjects with an adaptive immune response to the SARS-CoV-2 virus. Anti-human immunoglobulin antibodies allow for quick and simple, yet reliable assays with easy readouts and can also be adapted for high-throughput screening.

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