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I117

Sigma-Aldrich

R(+)-IAA-94

≥98% (HPLC), solid

别名:

R(+)-[(6,7-二氯-2-环戊基-2,3-二氢-2-甲基-1-氧代-1H-茚满-5-基)-氧]乙酸, R(+)-甲基吲唑酮, 茚满基含氧乙酸 94

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About This Item

经验公式（希尔记法）:
C17H18Cl2O4
CAS号:
54197-31-8
分子量:
357.23
分類程式碼代碼:
12352200
PubChem物質ID:
24277844
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

solid

光學活性

[α]22/D +36.4°, c = 0.86 in methanol(lit.)

顏色

white

溶解度

H2O: 0.2 mg/mL
0.1 M NaOH: 2.8 mg/mL
DMSO: >20 mg/mL
ethanol: 20 mg/mL
dilute aqueous acid: insoluble

儲存溫度

2-8°C

SMILES 字串

C[C@@]1(Cc2cc(OCC(O)=O)c(Cl)c(Cl)c2C1=O)C3CCCC3

InChI

1S/C17H18Cl2O4/c1-17(10-4-2-3-5-10)7-9-6-11(23-8-12(20)21)14(18)15(19)13(9)16(17)22/h6,10H,2-5,7-8H2,1H3,(H,20,21)/t17-/m1/s1

InChI 密鑰

RNOJGTHBMJBOSP-QGZVFWFLSA-N

應用

R(+)-IAA-94已被用作氯离子通道抑制剂，用于研究其对人单核（THP-1）细胞摄取格氟沙星的影响。它还被用作氯离子通道抑制剂，用于研究其对人单核（THP-1）细胞摄取莫西沙星的影响。

特點和優勢

该化合物在受体分类和信号转导手册的氯化物通道页面上有重点介绍。想要浏览手册的其他页面， 请单击此处。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
084M4606V
090M4606
015K4608

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D M Briggs Boedtkjer et al.
Pflugers Archiv : European journal of physiology, 457(2), 389-404 (2008-06-10)
The possibility that Ca(2+)-activated Cl(-) conductances (CaCCs) contribute to oscillations in vascular tone (vasomotion) is tested in isolated mesenteric small arteries from rats where cGMP independent (I (Cl(Ca))) and cGMP-dependent (I (Cl(Ca,cGMP))) chloride conductances are important. The effect of anion
Roberto J Diaz et al.
Cardiovascular research, 87(3), 545-551 (2010-03-17)
We have previously shown that reduction of ischaemic cell swelling via enhanced cell volume regulation is a key mechanism of ischaemic preconditioning (IPC) in cardiomyocytes. We have also shown that pharmacological blockade of Cl(-) channels abolishes cardioprotection achieved by IPC
Human THP-1 monocyte uptake and cellular disposition of 14C-grepafloxacin
Hall I H, et al.
Journal of Infection and Chemotherapy, 10(1), 11-18 (2004)
D W Landry et al.
The Journal of general physiology, 90(6), 779-798 (1987-12-01)
Chloride channels are present in the majority of epithelial cells, where they mediate absorption or secretion of NaCl. Although the absorptive and secretory channels are well characterized in terms of their electrophysiological behavior, there is a lack of pharmacological ligands
Indanyloxyacetic acid-sensitive chloride channels from outer membranes of skeletal muscle.
Weber-Schurholz S, et al.
The Journal of Biological Chemistry, 268(9), 547-551 (1993)
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