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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
產品線
Prestige Antibodies® Powered by Atlas Antibodies
形狀
buffered aqueous glycerol solution
物種活性
human
加強驗證
orthogonal RNAseq
independent
Learn more about Antibody Enhanced Validation
技術
immunohistochemistry: 1:50- 1:200
免疫原序列
LPFWGQPSDENCFEDAVYWEMPEGNSTVYIPEDPTFKPSGPSVPSVPMVSPLPMASSV
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... RHCG(51458)
一般說明
The Rh family C glycoprotein (RHCG) gene is mapped to human chromosome 15q26.1. RHCG is a non-erythrocytic protein and is a member of ammonia transporters (Amt)/ methylammonium permeases (MEP)/ rhesus (Rh) family of proteins. RHCG is mainly localized in the connecting tubule, in the collecting duct of the mammalian nephron as well as in the variety of extra renal tissues.
免疫原
Rh family, C glycoprotein recombinant protein epitope signature tag (PrEST)
應用
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
生化／生理作用
Rh family C glycoprotein (RHCG) facilitates the transport of ammonium across plasma membranes, to inhibit toxic accumulation of ammonium formed particularly during glutamine metabolism. In addition, it also increases acid secretion in the collecting duct (CD) by stimulating the transport of not only NH3 but also CO2 across the membranes of CD cells. Loss of gene expression leads to the development of human oesophageal cancer.
特點和優勢
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
聯結
Corresponding Antigen APREST81968
外觀
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
法律資訊
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Weighted gene co-expression based biomarker discovery for psoriasis detection
Sundarrajan S and Arumugam M
Gene, 593(1), 225-234 (2016)
RhCG is downregulated in oesophageal squamous cell carcinomas, but expressed in multiple squamous epithelia
Chen BS, et al.
European Journal of Cancer, 38(14), 1927-1936 (2002)
Functional reconstitution into liposomes of purified human RhCG ammonia channel
Mouro-Chanteloup I, et al.
PLoS ONE, 5(1), e8921-e8921 (2010)
Relative CO 2/NH 3 permeabilities of human RhAG, RhBG and RhCG
Geyer RR, et al.
The Journal of Membrane Biology, 246(12), 915-926 (2013)
Mechanism of NH4+ recruitment and NH3 transport in Rh proteins
Baday S, et al.
Structure, 23(8), 1550-1557 (2015)
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