H5914

N^α-甲基组胺 二盐酸盐

solid

• 别名: N-Methyl-1H-imidazole-4-ethanamine dihydrochloride, NAMH dihydrochloride
• 经验公式（希尔记法）: C₆H₁₁N₃ · 2HCl
• CAS号: 16503-22-3
• 分子量: 198.09
• MDL號碼: MFCD00134838
• 分類程式碼代碼: 12352116
• PubChem物質ID: 24724503
• NACRES: NA.77

属性

• 形狀: solid
• 顏色: white
• 溶解度: H₂O: >20 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: Cl[H].Cl[H].CNCCc1c[nH]cn1
• InChI: 1S/C6H11N3.2ClH/c1-7-3-2-6-4-8-5-9-6;;/h4-5,7H,2-3H2,1H3,(H,8,9);2*1H
• InChI 密鑰: AYUQICXJAMPXPF-UHFFFAOYSA-N

说明

生化／生理作用

Nα-Methylhistamine dihydrochloride helps in removing or decreasing the headache in migraine prophylaxis. It is highly effective than histamine in inducing cyclic adenosine 3′,5′-monophosphate (cAMP) synthesis.

Production of N-alpha-methyl-histamine (NAMH), a histamine H(3) receptor (H3R) agonist, is promoted in Helicobacter pylori infected human gastric mucosa. NAMH acts directly on histamine H(2) receptors (H2Rs) in animals to stimulate acid secretion and to be a H2R agonist. NAMH dose dependently stimulated cAMP productions in CHO-H2R cells. This production was inhibited by famotidine but not by thioperamide. Control CHO cells were unresponsive to either histamine or NAMH. In addition, the effect of NAMH, in terms of cAMP production in CHO-H2R cells, was more potent than that of histamine-that is, with a lower EC₅₀ concentration and higher maximal cAMP production. Both NAMH and histamine, but not R-alpha-methyl-histamine, effectively inhibited [(3)H] tiotidine binding to CHO-H2R cells. These results confirm that NAMH, which is produced in the gastric mucosa by H pylori, is a potent H2R agonist as well as a H3R agonist.

特點和優勢

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

品質

The product is pure based on elemental analysis results, NMR and MS spectra.

安全信息

• 象形圖: GHS05,GHS07
• 訊號詞: Danger
• 危險聲明: H302,H315,H318,H335
• 防範說明: P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310
• 危險分類: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves