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Merck

H5653

Sigma-Aldrich

8-羟基-2′-脱氧鸟苷

≥98% (TLC), DNA damage biomaker

别名:

8-氧代-7,8-二氢-2′-脱氧鸟苷, 8-氧代-dG

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About This Item

经验公式(希尔记法):
C10H13N5O5
CAS号:
分子量:
283.24
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

product name

8-羟基-2′-脱氧鸟苷, ≥98% (TLC)

品質等級

化驗

≥98% (TLC)

儲存溫度

2-8°C

SMILES 字串

O=C1C(NC(N2C3CC(O)C(CO)O3)=O)=C2NC(N)=N1

InChI

1S/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)

InChI 密鑰

HCAJQHYUCKICQH-UHFFFAOYSA-N

應用

8-羟基-2′-脱氧鸟苷已用于以下情形:
  • 作为标准品,通过电化学检测分析正常和异常妊娠胎盘中的氧化DNA损伤
  • 借助电化学检测(ECD),作为标准品用于高效液相色谱法(HPLC)
  • 作为HPLC标准品和氧化应激尿液标志物,评估绿咖啡豆提取物的潜在抗氧化活性(GCBE) 体内
  • 作为标准品用于LC/MS/MS分析

生化/生理作用

8-羟基-2′-脱氧鸟苷的水平有助于评估喉癌个体的氧化应激和DNA损伤。因此它可以用作活性氧(ROS)诱导DNA损伤的主要生物标志物。
标记化合物通常指示与诱变和致癌作用相关的DNA损伤

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Measuring oxidative DNA damage with 8-hydroxy-2?-deoxyguanosine levels in patients with laryngeal cancer
Mazlumoglu M R, et al.
The Annals of Otology, Rhinology, and Laryngology, 126(2), 103-109 (2017)
Helena Beatriz Ferreira et al.
Journal of pharmaceutical and biomedical analysis, 174, 386-395 (2019-06-18)
Autoimmune diseases (AID) are a heterogeneous group of disorders that have in common a chronic inflammation and dysregulation of the immune system. Systemic lupus erythematosus (SLE) is one of the most frequent systemic autoimmune diseases characterized by autoimmune phenomena in
Nikhat J Siddiqi et al.
Journal of neuroinflammation, 9, 123-123 (2012-06-14)
Gold nanoparticles (AuNPs) are finding increased use in therapeutics and imaging. However, their toxic effects still remain to be elucidated. Therefore this study was undertaken to study the biochemical effects of AuNPs on rat brain and identify potential biomarkers of
Pan Chen et al.
Life sciences, 232, 116594-116594 (2019-06-25)
Sleep deficiency has been reported to be associated with some oral health problems. Oral ulcers are very common lesions of the oral mucosa, which severely impact patients' quality of life. However, the association between sleep deficiency and the oral ulcer
Elisabeth Müllner et al.
Molecular nutrition & food research, 57(2), 328-338 (2012-11-14)
Type 2 diabetes is a multifactorial disease associated with increased oxidative stress, which may lead to increased DNA damage. The aim of this study was to investigate the effect of a healthy diet on DNA oxidation in diabetics and nondiabetics.

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