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Merck

H2504

Sigma-Aldrich

His-Leu

≥98% (TLC), suitable for ligand binding assays

别名:

histidylleucine

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About This Item

经验公式(希尔记法):
C12H20N4O3
CAS号:
分子量:
268.31
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.26

product name

His-Leu,

化驗

≥98% (TLC)

品質等級

形狀

solid

技術

ligand binding assay: suitable

顏色

white to off-white

儲存溫度

−20°C

SMILES 字串

CC(C)CC(NC(=O)C(N)Cc1cnc[nH]1)C(O)=O

InChI

1S/C12H20N4O3/c1-7(2)3-10(12(18)19)16-11(17)9(13)4-8-5-14-6-15-8/h5-7,9-10H,3-4,13H2,1-2H3,(H,14,15)(H,16,17)(H,18,19)

InChI 密鑰

MMFKFJORZBJVNF-UHFFFAOYSA-N

生化/生理作用

Histidylleucine (His-Leu); histidylglycine (His-Gly) and histidylserine (His-Ser) are N-terminal imidazole containing dipeptides used to study binding of metals such as copper, nickel and zinc.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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R A Santos et al.
Hypertension (Dallas, Tex. : 1979), 7(2), 244-252 (1985-03-01)
The most sensitive nonradiometric routine assay for angiotensin-converting enzyme (ACE) activity uses fluorometry to detect His-Leu released from Hip-His-Leu. Our results indicate that, in contrast to human serum, rat serum and plasma contain large and variable amounts of dipeptidase activity
J B Vita et al.
Investigative ophthalmology & visual science, 20(2), 255-257 (1981-02-01)
Angiotensin II is a biological active octapeptide that is formed by the action of angiotensin-converting enzyme (ACE) on the inactive precursor, angiotensin I. ACE activity was found in tears and aqueous humor from both rabbit and human eyes. The activity
V Schusdziarra et al.
Peptides, 7(1), 127-133 (1986-01-01)
Bombesin-like immunoreactivity (BLI) has been demonstrated in neurons of the gastrointestinal tract and gastric BLI secretion can be demonstrated in response to the classical neurotransmitter acetylcholine. Since structurally related peptides VIP, PHI and GRF have to be considered as peptidergic
K Iwatsuki et al.
Clinical and experimental pharmacology & physiology, 20(7-8), 501-507 (1993-07-01)
1. The effects of peptide histidine isoleucine (PHI) on pancreatic exocrine secretion were investigated in preparations of the isolated and blood-perfused dog pancreas as compared with those of vasoactive intestinal peptide (VIP), secretin and glucagon. 2. Each peptide tested was
S Ceccatelli et al.
Neuroendocrinology, 49(3), 309-323 (1989-03-01)
The distribution of several peptides, corticotropin-releasing factor (CRF), neurotensin (NT), enkephalin (ENK), vasoactive intestinal polypeptide (VIP), peptide histidine isoleucine (PHI), cholecystokinin (CCK), thyrotropin-releasing hormone (TRH) and galanin (GAL) was studied in detail with immunohistochemistry in the various subdivisions of the

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