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About This Item
经验公式（希尔记法）:
C9H11NO5
CAS号:
分子量:
213.19
Beilstein:
2860065
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.32
推荐产品
产品名称
6-羟基-DL-多巴, ≥98% (HPLC), powder
品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
off-white
溶解度
H2O: 3 mg/mL
1 M HCl: 50 mg/mL (Solutions should be freshly prepared and protected from exposure to light.)
儲存溫度
−20°C
SMILES 字串
NC(Cc1cc(O)c(O)cc1O)C(O)=O
InChI
1S/C9H11NO5/c10-5(9(14)15)1-4-2-7(12)8(13)3-6(4)11/h2-3,5,11-13H,1,10H2,(H,14,15)
InChI 密鑰
YLKRUSPZOTYMAT-UHFFFAOYSA-N
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一般說明
Dissolve in oxygen-free boiled water containing 0.1% sodium metabisulfite or other antioxidant. Solutions should be freshly prepared and protected from exposure to light.
生化／生理作用
6-羟基-DL-DOPA是APE1（紫杉醇/嘧啶内切核酸酶）修复功能活性的一种抑制剂。APE1是一种对DNA碱基切除修复途径至关重要的核酸酶。6-羟基-DL-DOPA还可封闭RAD52（DNA修复蛋白）单链DNA结合结构域。
儿茶酚胺能神经毒素6-羟基多巴胺的前体；通过L-芳族氨基酸脱羧酶转化为6-羟基多巴胺。
包裝
无底玻璃瓶。内含物在插入的融合锥体内。
注意
吸湿；光敏感
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Gurushankar Chandramouly et al.
Chemistry & biology, 22(11), 1491-1504 (2015-11-10)
Suppression of RAD52 causes synthetic lethality in BRCA-deficient cells. Yet pharmacological inhibition of RAD52, which binds single-strand DNA (ssDNA) and lacks enzymatic activity, has not been demonstrated. Here, we identify the small molecule 6-hydroxy-DL-dopa (6-OH-dopa) as a major allosteric inhibitor
A J Nappi et al.
Pigment cell research, 8(6), 283-293 (1995-12-01)
High pressure liquid chromatography with electrochemical detection (HPLC-ED) was employed in conjugation with a sensitive and specific salicylate hydroxylation assay to evaluate the immediate effects of hydroxyl radical (.OH) attack on four catechol intermediates of eumelanin, dopamine (3,4-dihydroxyphenylethylamine), its precursor
A Padiglia et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 4(5), 608-613 (1999-11-07)
The reaction with substrates and carbonyl reagents of native lentil Cu-amine oxidase and its modified forms, i.e. Cu-fully-depleted, Cu-half-reconstituted, Cu-fully-reconstituted, Co-substituted, Ni-substituted and Zn-substituted, has been studied. Upon removal of only one of the two Cu ions, the enzyme loses
P Oguzkurt et al.
British journal of urology, 82(1), 104-108 (1998-08-12)
To evaluate the effects of vasodilator therapies and chemical sympathectomy on ipsilateral and contralateral testicular spermatogenetic activity after unilateral testicular torsion using DNA flow cytometry and thus determine whether contralateral testicular damage occurs through a reflexively decreased blood flow. The
A J Nappi et al.
Biochimica et biophysica acta, 1201(3), 498-504 (1994-12-15)
The interactions of ascorbic acid (AA) and reduced glutathione (GSH) in the oxidations of the catecholaminergic neurotoxins 6-hydroxydopa (TOPA) and 6-hydroxydopamine (6-OHDA) were investigated by both high performance liquid chromatography with electrochemical detection (HPLC-ED) and spectrometric methods. These comparative studies
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