推荐产品
生物源
chicken
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
human
製造商／商標名
Genway 15-288-21011
技術
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... ADRB2(154)
一般說明
β-2 Adrenergic Receptor is a member of the seven-transmembrane-domain receptor family. The ADRB2 gene is mapped on the human chromosome at 5q32. β-2 Adrenergic Receptor is a seven-transmembrane protein that consists of α helices. The N-terminal is extracellular whereas the C-terminal is intracellular.
免疫原
Immunogen Sequence: GI # 4501969, sequence 335-408
Recombinant adrenergic, β-2-, receptor, surface
應用
Anti-β-2 Adrenergic Receptor antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生化／生理作用
The β-2 adrenergic receptor (β2 adrenoreceptor), also known as ADRB2, is present within a cell membrane. It reacts with adrenaline (epinephrine) as a hormone or neurotransmitter affecting muscles or organs. It may be a risk factor for chronic pain and its polymorphisms may influence labor pain. It contains a common non-synonymous single nucleotide polymorphism. Epinephrine activates ADRB2 impairing keratinocyte migration. β2-adrenoceptor pathway is essential for cardiovascular regulation.
外觀
Solution in phosphate buffered saline containing 0.02% sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
U H Frey et al.
British journal of anaesthesia, 112(3), 477-484 (2013-12-25)
While the β2-adrenoceptor pathway is essential for cardiovascular regulation, the impact of ADRB2 gene variations on circulatory responses is unclear, possibly due to neural compensatory mechanisms. We tested the hypotheses that (i) sympathetic block by thoracic epidural anaesthesia (TEA) unmasks
Dennis W McGraw et al.
Proceedings of the American Thoracic Society, 2(4), 292-296 (2005-11-04)
It is now clear that the beta2-adrenergic receptor continuously oscillates between various conformations in the basal state, and that agonists act to stabilize one or more conformations. It is conceivable that synthetic agonists might be engineered to preferentially confine the
R A Hall et al.
Nature, 392(6676), 626-630 (1998-04-29)
Stimulation of beta2-adrenergic receptors on the cell surface by adrenaline or noradrenaline leads to alterations in the metabolism, excitability, differentiation and growth of many cell types. These effects have traditionally been thought to be mediated exclusively by receptor activation of
Victor E Ortega et al.
The Lancet. Respiratory medicine, 2(3), 204-213 (2014-03-14)
Severe adverse life-threatening events associated with longacting β agonist (LABA) use have caused the US Food and Drug Administration (FDA) to review the safety of these drugs, resulting in a boxed warning and a mandatory safety study in 46 800 patients
Abdullah S Terkawi et al.
Anesthesiology, 121(1), 140-148 (2014-04-10)
Variability in labor pain has been associated with demographic, clinical, and psychological factors. Polymorphisms of the β2-adrenergic receptor gene (ADRB2) influence sensitivity to experimental pain in humans and are a risk factor for chronic pain. The authors hypothesized that polymorphisms
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