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G0759

Sigma-Aldrich

甘氨鹅脱氧胆酸钠

别名:

3α,7α-二羟基-5β-胆烷酸 N-（羧甲基）酰胺 钠盐, N-(3α,7α-二羟基-24-氧代胆烷-24-基)甘氨酸 钠盐, 甘氨鹅脱氧胆酸 钠盐

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About This Item

经验公式（希尔记法）:
C26H42NNaO5
CAS号:
16564-43-5
分子量:
471.61
Beilstein:
3847290
MDL號碼:
MFCD00036743
分類程式碼代碼:
12161900
PubChem物質ID:
24895023
NACRES:
NA.25

描述

anionic

形狀

powder

分子量

471.61 g/mol

技術

HPLC: suitable
protein quantification: suitable

官能基

sulfonic acid

運輸包裝

ambient

儲存溫度

room temp

SMILES 字串

[Na+].C[C@H](CCC(=O)NCC([O-])=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C26H43NO5.Na/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29;/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32);/q;+1/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-;/m1./s1

InChI 密鑰

AAYACJGHNRIFCT-YRJJIGPTSA-M

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相关类别

一般說明

甘氨鹅脱氧胆酸盐 (GCDC) 是一种有毒的疏水性胆汁盐。

應用

甘氨鹅去氧胆酸钠已被用作 de Man、Rogosa 和 Sharpe (MRS) 琼脂中的添加剂，用于胆汁酸解偶联，测定菌株解偶联特定胆汁酸的能力。
甘氨鹅脱氧胆酸钠已可用于评估胆汁盐诱导的DNA损伤的修复。 它还被用于研究A型产气荚膜梭菌( Clostridium perfringens ）在人胆汁盐存在下的肠毒素产生。

生化／生理作用

甘氨鹅脱氧胆酸盐 (GCDC) 可诱导部分由 Fas 介导的肝细胞凋亡。

取代透過

产品编号
说明
价格

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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N L Heredia et al.
FEMS microbiology letters, 68(1), 15-21 (1991-11-01)
The effect of human bile juice and bile salts (sodium cholate, sodium taurocholate, sodium glycochenodeoxycholate and sodium chenodeoxycholate) on growth, sporulation and enterotoxin production by enterotoxin-positive and enterotoxin-negative strains of Clostridium perfringens was determined. Each bile salt inhibited growth to
Lin Lin et al.
American journal of translational research, 11(6), 3365-3374 (2019-07-18)
Human noroviruses (HuNoVs) are a major cause of epidemic and sporadic cases of acute gastroenteritis worldwide. Recently, human intestinal enteroids (HIEs) have been shown to support the replication of HuNoVs, and be an excellent model to study HuNoV-host interactions. We
Ana I Prieto et al.
Genetics, 174(2), 575-584 (2006-08-05)
Exposure of Salmonella enterica to sodium cholate, sodium deoxycholate, sodium chenodeoxycholate, sodium glycocholate, sodium taurocholate, or sodium glycochenodeoxycholate induces the SOS response, indicating that the DNA-damaging activity of bile resides in bile salts. Bile increases the frequency of GC -->
Reid L Wilson et al.
Tissue engineering. Part C, Methods, 27(1), 12-23 (2020-12-19)
Stem cell-derived, organotypic in vitro models, known as organoids, have emerged as superior alternatives to traditional cell culture models due to their unparalleled ability to recreate complex physiological and pathophysiological processes. For this reason, they are attractive targets of tissue-engineering
Hanno Ehlken et al.
PloS one, 6(10), e25942-e25942 (2011-10-25)
Mice lacking the Abc4 protein encoded by the multidrug resistance-2 gene (Mdr2(-/-)) develop chronic periductular inflammation and cholestatic liver disease resulting in the development of hepatocellular carcinoma (HCC). Inhibition of NF-κB by expression of an IκBα super-repressor (IκBαSR) transgene in
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