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品質等級
化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
light yellow to yellow
溶解度
DMSO: ≥10 mg/mL
儲存溫度
2-8°C
InChI
1S/C18H18N2S.BrH/c1-3-4-16-11-15(9-10-19-16)18-20-17(12-21-18)14-7-5-13(2)6-8-14;/h5-12H,3-4H2,1-2H3;1H
InChI 密鑰
RJCFNQZVFUMORB-UHFFFAOYSA-N
一般說明
Fatostatin是一种非固醇二芳基噻唑衍生物。它可防止胰岛素诱导的脂肪生成，并降低脂肪酸、甘油三酯和低密度脂蛋白的含量。Fatostatin具有抗肿瘤和抗有丝分裂特性。
應用
Fatostatin氢溴酸已被用于：
- 研究其抗癌活性以及对有丝分裂微管纺锤体的影响
- 研究其对气孔发育的影响
- 防止SREBP切割活化蛋白介导的固醇调控元件集合蛋白（SREBP）护送
生化／生理作用
Fatostatin氢溴酸是一种SREBP抑制剂。Fatostatin氢溴酸可通过抑制SREBP（固醇调节元素结合蛋白）来抑制小鼠脂肪的产生并降低葡萄糖水平。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Inhibition of cell polarity establishment in stomatal asymmetric cell division using the chemical compound bubblin
Sakai Y, et al.
Development, dev-145458 (2017)
Fatostatin displays high antitumor activity in prostate cancer by blocking SREBP-regulated metabolic pathways and androgen receptor signaling
Li X, et al.
Molecular Cancer Therapeutics, 13(4), 855-866 (2014)
Yumiko Sakai et al.
Development (Cambridge, England), 144(3), 499-506 (2017-01-15)
Stem cell polarization is a crucial step in asymmetric cell division, which is a universal system for generating cellular diversity in multicellular organisms. Several conventional genetics studies have attempted to elucidate the mechanisms underlying cell polarization in plants, but it
Chih-Ming Huang et al.
Cells, 9(1) (2019-12-22)
: Elevated activity of sterol regulatory element-binding protein 1 (SREBP1) has been implicated in the tumorigenesis of different cancer types. However, the functional roles of SREBP1 in esophageal cancer are not well appreciated. Here, we aimed to investigate the therapeutic
Fatostatin inhibits cancer cell proliferation by affecting mitotic microtubule spindle assembly and cell division.
Gholkar A A, et al.
The Journal of Biological Chemistry, 291(33), 17001-17008 (2016)
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