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![6-[Bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-2(1H)-quinolinone analytical standard](/deepweb/assets/sigmaaldrich/product/structures/182/124/8af6c3bd-3ba2-404c-b2a6-ba9ac211cea0/640/8af6c3bd-3ba2-404c-b2a6-ba9ac211cea0.png)
生物源
synthetic (organic)
品質等級
化驗
≥98% (HPLC)
形狀
solid
技術
HPLC: suitable
gas chromatography (GC): suitable
溶解度
chloroform: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
應用
forensics and toxicology
veterinary
儲存溫度
2-8°C
SMILES 字串
C[C@]12CC[C@H]3[C@@H](CCC4=C(O)C(=O)CC[C@]34C)[C@@H]1CCC2=O
InChI
1S/C19H26O3/c1-18-10-8-15(20)17(22)14(18)4-3-11-12-5-6-16(21)19(12,2)9-7-13(11)18/h11-13,22H,3-10H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1
InChI 密鑰
OSVMTWJCGUFAOD-KZQROQTASA-N
基因資訊
human ... CYP19A1(1588)
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生化／生理作用
Aromatase inhibitor used as an anti-cancer agent against estrogen-dependent tumors.
訊號詞
Danger
危險聲明
危險分類
Repr. 1B
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
個人防護裝備
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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The Journal of endocrinology, 190(3), 749-757 (2006-09-28)
Ghrelin, an endogenous ligand for the GH secretagogue receptor, is predominantly produced in the stomach. Little is known about the regulation mechanism of gastric ghrelin. Here, we report that estrogen synthesized in the stomach induces rat gastric ghrelin gene expression
P E Lønning
Breast cancer research and treatment, 49 Suppl 1, S45-S52 (1998-10-31)
Steroidal aromatase inhibitors like formestane and exemestane are useful drugs for endocrine treatment of postmenopausal breast cancer. In addition, these drugs should be considered valuable probes to explore the biology of breast cancer with particular emphasis on possible relations between
Aaron T Wright et al.
Journal of the American Chemical Society, 131(30), 10692-10700 (2009-07-09)
Cytochrome P450 (P450) enzymes regulate a variety of endogenous signaling molecules and play central roles in the metabolism of xenobiotics and drugs. We recently showed that an aryl alkyne serves as an effective activity-based probe for profiling mouse liver microsomal
Sanjay K Sharma et al.
Bioorganic & medicinal chemistry letters, 18(20), 5563-5566 (2008-09-26)
Synthesis of 4-amino-4,6-androstadiene-3,17-dione 7, an analog of formestane used in breast cancer therapy as an aromatase inhibitor, from 4-acetoxy-4-androstene-3,17-dione 2 is described. This is the first report of a 4-amino diene (4,6) system in this series of molecules. The new
P E Lønning et al.
The Journal of steroid biochemistry and molecular biology, 77(1), 39-47 (2001-05-19)
Formestane (Lentaron(R), 4-hydroxyandrostenedione) is a steroidal aromatase inhibitor used for treatment of advanced breast cancer. Clinically, it is administered as a depot form once fortnightly by intramuscular (i.m.) injection. To investigate the pharmacokinetics, bioavailability and metabolism of the drug, seven
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