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About This Item
经验公式（希尔记法）:
C11H17N4O13P3
CAS号:
分子量:
506.19
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.52
推荐产品
生物源
Porcine muscle
rabbit muscle
品質等級
化驗
≥95% (HPLC)
形狀
liquid
濃度
10 mM in H2O
顏色
colorless
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
NC1=NC(=O)c2ccn(C3CC(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O3)c2N1
InChI
1S/C11H17N4O13P3/c12-11-13-9-5(10(17)14-11)1-2-15(9)8-3-6(16)7(26-8)4-25-30(21,22)28-31(23,24)27-29(18,19)20/h1-2,6-8,16H,3-4H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,12,13,14,17)
InChI 密鑰
DLLXAZJTLIUPAI-UHFFFAOYSA-N
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應用
7-脱氮-2′-脱氧鸟苷-5′-三磷酸锂盐已用作裂解剂，评估其直接细胞裂解的效率、RNA稳定性，以及在分析少量细胞样品时与下游逆转录定量实时PCR的兼容性。
生化／生理作用
7-脱氮-2′-脱氧鸟苷-5′-三磷酸 (7-deaza-dGTP) 与天然底物 dGTP 竞争并阻断端粒酶活性。该核苷酸掺入端粒后，会即刻改变端粒的二级结构，使端粒酶难以识别它，无法进一步合成端粒。这种dGTP类似物可与常规碱基弱配对，最大限度地减少DNA二级结构的形成，同时成为DNA聚合酶的良好底物。7-deaza-dGTP与二甲基亚砜 (DMSO) 和甜菜碱结合使用可增强富含GC的 DNA 序列的聚合酶链式反应 (PCR) 扩增。
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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Roger Pamphlett et al.
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Gene mutations that preferentially affect the CNS have been implicated in a number of neurological disorders. This leads to the possibility that a disease-causing mutation present only in CNS tissues could be missed if it were tested in a blood
7-Deaza-2-deoxyguanosine allows PCR and sequencing reactions from CpG islands
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PLoS genetics, 2(12), e214-e214 (2006-12-30)
Arthrobacter sp. strains are among the most frequently isolated, indigenous, aerobic bacterial genera found in soils. Member of the genus are metabolically and ecologically diverse and have the ability to survive in environmentally harsh conditions for extended periods of time.
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