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Merck

D7071

Sigma-Aldrich

达泊西汀 盐酸盐

≥98% (HPLC)

别名:

(S)-(+)-N,N-二甲基-1-苯基-3-(1-萘氧基)丙胺盐酸盐, (S)-(+)-N,N-二甲基-a-[2-(萘氧基)乙基]苯甲胺盐酸盐,LY-210448 盐酸盐

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About This Item

经验公式(希尔记法):
C21H23NO · HCl
分子量:
341.87
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

光學活性

[α]/D +125 to +135°, c = 1 in methanol

儲存條件

desiccated

顏色

white

溶解度

DMSO: ≥20 mg/mL

起源

Eli Lilly

儲存溫度

room temp

SMILES 字串

Cl.CN(C)[C@@H](CCOc1cccc2ccccc12)c3ccccc3

InChI

1S/C21H23NO.ClH/c1-22(2)20(18-10-4-3-5-11-18)15-16-23-21-14-8-12-17-9-6-7-13-19(17)21;/h3-14,20H,15-16H2,1-2H3;1H/t20-;/m0./s1

InChI 密鑰

IHWDIQRWYNMKFM-BDQAORGHSA-N

基因資訊

human ... SLC6A4(6532)

一般說明

达泊西汀((+)-(S)-N,N-二甲基-(α)-[2(1萘氧基)乙基]-苯甲胺盐酸盐)的结构类似于氟西汀。

生化/生理作用

有效的选择性5-羟色胺再摄取抑制剂(SSRI);用于治疗早泄
达泊西汀可阻断重组Kv4.3电压门控钾通道。已确认为安全的治疗药物。

特點和優勢

该化合物收录于 受体分类和信号转导手册的《生物胺转运体 》页面。想要浏览手册的其他页面, 请单击此处
该化合物由Eli Lilly开发。要浏览其他药物开发化合物和批准的药物/候选药物列表,单击此处

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Irrit. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Premature ejaculation (PE) is classified as an acquired or lifelong condition but data on baseline characteristics and response to treatment of men with acquired or lifelong PE and mild erectile dysfunction (ED) or normal erectile function (EF) is limited. To
Imju Jeong et al.
European journal of pharmacology, 805, 36-45 (2017-03-23)
Selective serotonin reuptake inhibitors (SSRIs) have an inhibitory effect on various ion channels including Ca
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Drugs, 70(11), 1433-1443 (2010-07-10)
Dapoxetine, a selective serotonin reuptake inhibitor, is the first oral pharmacological agent indicated for the treatment of men aged 18-64 years with premature ejaculation. In four randomized, double-blind, placebo-controlled, multicentre studies of 12-24 weeks' duration, oral dapoxetine 30 or 60
Kate Hutchinson et al.
Drug safety, 35(5), 359-372 (2012-03-29)
Premature ejaculation (PE) is considered to be the most common sexual problem affecting men, despite the likelihood that it is under-diagnosed. It is a complex condition with many physical and psychological components, making management complicated. It is important to develop

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These distinct transporters, NET, DAT and SERT, respectively, are of particular clinical interest because they are the molecular targets for many antidepressants as well as drugs of abuse, such as cocaine and the amphetamines.

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