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生物源
synthetic
品質等級
形狀
powder
顏色
dark red-purple to black
溶解度
ethanol: ~10 mg/mL (lit.)
DMSO: >25 mg/mL (lit.)
抗生素活性譜
neoplastics
作用方式
protein synthesis | interferes
儲存溫度
−20°C
一般說明
Chemical structure: benzenoid
應用
17-DMAG has been used to block the NF-κB inflammatory cascade in the murine model. It a potential therapeutic agent for non-small-cell lung cancers (NSCLC).
生化／生理作用
17-DMAG is a heat shock protein (HSP90) inhibitor. 17-DMAG is a more potent analog of geldanamycin. It inhibits cancer growth and promotes apoptosis in multiple cell lines. 17-DMAG is a more potent antitumor agent than 17-AAG.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
HSP90 inhibition by 17-DMAG reduces inflammation in J774 macrophages through suppression of Akt and nuclear factor-κB pathways.
Shimp SK 3rd, Parson CD, et al.
Inflammation Research, epub (2012)
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