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應用
人二肽基肽酶VIII已用于将ERGIC-53鉴定为α1-抗胰蛋白酶的细胞内转运受体的研究中。人二肽基肽酶VIII也已用于研究ERGIC-53/MCFD2转运受体复合物的货物选择性。
生化／生理作用
二肽基肽酶VIII（DPP8）是在细胞质中表达的100 kDa单体蛋白。它是一种后脯氨酸二肽基氨肽酶，与DPPIV和成纤维细胞活化蛋白（FAP）同源。它水解Ala-Pro、Arg-Pro和Gly-Pro。DPP8具有最佳的中性pH值。它可能参与T细胞活化和免疫功能，因为它与DPPIV相似。它在免疫激活过程中被上调。
物理性質
带有N端GST标签的全长序列
單位定義
一个单位为在pH 7.4，25℃下，每分钟水解1.0皮摩尔的Ala-Pro-AMC。
外觀
以溶于40 mM Tris-HCL, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT 和 20%甘油的溶液形式提供。
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
Beat Nyfeler et al.
The Journal of cell biology, 180(4), 705-712 (2008-02-20)
Secretory proteins are exported from the endoplasmic reticulum (ER) by bulk flow and/or receptor-mediated transport. Our understanding of this process is limited because of the low number of identified transport receptors and cognate cargo proteins. In mammalian cells, the lectin
Beat Nyfeler et al.
Traffic (Copenhagen, Denmark), 7(11), 1473-1481 (2006-10-03)
Exit of soluble secretory proteins from the endoplasmic reticulum (ER) can occur by receptor-mediated export as exemplified by blood coagulation factors V and VIII. Their efficient secretion requires the membrane lectin ER Golgi intermediate compartment protein-53 (ERGIC-53) and its soluble
C A Abbott et al.
European journal of biochemistry, 267(20), 6140-6150 (2000-09-30)
Dipeptidyl peptidase (DPP) IV has roles in T-cell costimulation, chemokine biology, type-II diabetes and tumor biology. Fibroblast activation protein (FAP) has been implicated in tumor growth and cirrhosis. Here we describe DPP8, a novel human postproline dipeptidyl aminopeptidase that is
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