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Merck

D0776

Sigma-Aldrich

2′-脱氧胞苷 盐酸盐

BioReagent, suitable for cell culture

别名:

1-(2-脱氧-β-D-呋喃核糖基)胞嘧啶 盐酸盐, 2'-脱氧胞嘧啶核苷 盐酸盐

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About This Item

经验公式(希尔记法):
C9H13N3O4 · HCl
CAS号:
分子量:
263.68
Beilstein:
3576124
EC號碼:
MDL號碼:
分類程式碼代碼:
12352207
PubChem物質ID:

生物源

synthetic

品質等級

產品線

BioReagent

化驗

≥99% (HPLC)

形狀

powder

技術

cell culture | mammalian: suitable

溶解度

water: 50 mg/mL, clear, colorless

SMILES 字串

Cl[H].NC1=NC(=O)N(C=C1)[C@H]2C[C@H](O)[C@@H](CO)O2

InChI

1S/C9H13N3O4.ClH/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8;/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15);1H/t5-,6+,8+;/m0./s1

InChI 密鑰

LTKCXZGFJFAPLY-OERIEOFYSA-N

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應用

2′-脱氧胞苷盐酸盐已用于:
  • 作为基础培养基中的脱氧核糖核苷成分,研究其对莫哈韦芽孢杆菌′厌氧生长的影响
  • 通过人类免疫缺陷病毒 1 型(HIV-1)对单核细胞衍生巨噬细胞的感染性测定
  • 核苷补充剂,用于使人视网膜色素上皮-1(RPE-1)细胞在 G1 期同步

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Cell reports, 28(2), 434-448 (2019-07-11)
Cellular SAMHD1 inhibits replication of many viruses by limiting intracellular deoxynucleoside triphosphate (dNTP) pools. We investigate the influence of SAMHD1 on human cytomegalovirus (HCMV). During HCMV infection, we observe SAMHD1 induction, accompanied by phosphorylation via viral kinase UL97. SAMHD1 depletion
Md Maminur Rahman et al.
The Journal of biological chemistry, 295(51), 17460-17475 (2021-01-18)
Homologous recombination (HR) repairs DNA double-strand breaks using intact homologous sequences as template DNA. Broken DNA and intact homologous sequences form joint molecules (JMs), including Holliday junctions (HJs), as HR intermediates. HJs are resolved to form crossover and noncrossover products.
Ilaria Cascone et al.
The EMBO journal, 27(18), 2375-2387 (2008-08-30)
The Ras family G-proteins RalA and RalB make critical non-overlapping contributions to the generation of a tumorigenic regulatory network, supporting bypass of the normal restraints on both cell proliferation and survival. The Sec6/8 complex, or exocyst, has emerged as a
Aiman A Haqqani et al.
Virology journal, 12, 184-184 (2015-11-13)
Template switching between two distinct HIV-1 RNA genomes during reverse transcription gives rise to recombinant viruses that greatly expand the genetic diversity of HIV-1 and have adverse implications for drug resistance, immune escape, and vaccine design. Virions with two distinct
Francesco Morra et al.
Oncotarget, 6(14), 12697-12709 (2015-04-18)
CCDC6 gene product is a pro-apoptotic protein substrate of ATM, whose loss or inactivation enhances tumour progression. In primary tumours, the impaired function of CCDC6 protein has been ascribed to CCDC6 rearrangements and to somatic mutations in several neoplasia. Recently

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