生物源
human urine
品質等級
無菌
aseptically processed
形狀
lyophilized powder
效力
≥5,000 I.U. per mg
分子量
37.9 kDa
apparent mol wt 37.9 kDa by SDS-PAGE
drug control
Home Office Schedule 4.2
技術
cell culture | embryo: suitable
雜質
HBV,HCV and HIV, tested negative
溶解度
H2O: 1 mL/vial
saline: 1 mL/vial
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
基因資訊
human ... CGA(1081)
正在寻找类似产品? 访问 产品对比指南
一般說明
由 92 个氨基酸 α 链组成的糖蛋白激素，与 LH、FSH 和 TSH 相同； 和一个独特的 149 个氨基酸 β 链。由绒毛膜组织产生，负责在妊娠早期维持黄体。也由滋养层细胞肿瘤产生，其特征是游离 hCG β-链升高和高糖基化 hCG。
注意：根据糖基化程度的不同，实际分子量与理论值不同。该物质天然形式的理论分子量为 37.9kDa，且包含 2 个亚基：α = 14.9kDa（多肽部分 ~10.2kDa，碳水化合物部分 ~4.7kDa），β = 23.0kDa（多肽部分 ~16.0kDa，碳水化合物部分 ~7.0kDa）。参见 J. Biol. Chem. 248，6796-6827(1973)。
應用
推荐用于小鼠的超数排卵诱导。
生化／生理作用
Human chorionic gondadotropin (hCG) may be used as an alternative to PMSG to induce ovulation in laboratory animals. When hCG was injected into laboratory animals via intravenous (i.v.), intraperitoneal (i.p.), or subcutaneous (s.c.) methodstet, the effective dose values for 50% of the animals (ED50) per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.2 (7.7) I.U.; i.p. 0.3 (11.5) I.U.; s.c. 0.7 (26.9) I.U.
Syrian hamsters: i.v. 1.0 (9.5) I.U.; i.p. 1.8 (17.1) I.U.; s.c. 2.6 (24.8) I.U.
Rats: i.v. 1.3 (4.6) I.U.; i.p. 3.5 (12.3) I.U.; s.c.7.5 (26.3) I.U.
Using PMSG, the ED50 values per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.8 (30.8) I.U.; i.p. 2.0 (76.9) I.U.; s.c. 2.8 (107.7) I.U
Syrian hamsters: i.v., 3.6 (34.3) I.U.; i. p., 8.0 (76.2) I.U.; s.c., 13.2 (125.7) I.U.
Rats: i.v., 6.0 (76.8) I.U.; i p., 20.8 (73.0) I.U.; s.c., 76.8 (269.5) I.U.
Mice: i.v. 0.2 (7.7) I.U.; i.p. 0.3 (11.5) I.U.; s.c. 0.7 (26.9) I.U.
Syrian hamsters: i.v. 1.0 (9.5) I.U.; i.p. 1.8 (17.1) I.U.; s.c. 2.6 (24.8) I.U.
Rats: i.v. 1.3 (4.6) I.U.; i.p. 3.5 (12.3) I.U.; s.c.7.5 (26.3) I.U.
Using PMSG, the ED50 values per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.8 (30.8) I.U.; i.p. 2.0 (76.9) I.U.; s.c. 2.8 (107.7) I.U
Syrian hamsters: i.v., 3.6 (34.3) I.U.; i. p., 8.0 (76.2) I.U.; s.c., 13.2 (125.7) I.U.
Rats: i.v., 6.0 (76.8) I.U.; i p., 20.8 (73.0) I.U.; s.c., 76.8 (269.5) I.U.
Styliani Markoulaki et al.
Methods (San Diego, Calif.), 45(2), 101-114 (2008-07-03)
Addressing the fundamental questions of nuclear equivalence in somatic cells has fascinated scientists for decades and has resulted in the development of somatic cell nuclear transfer (SCNT) or animal cloning. SCNT involves the transfer of the nucleus of a somatic
David R J Glenn et al.
Fertility and sterility, 91(3), 893-899 (2008-03-08)
To determine the effects of sildenafil citrate, a cyclic monophosphate-specific type 5 phosphodiesterase inhibitor known to affect sperm function, on fertilization and early embryo cleavage. This acute mammal study included male and female mice assigned randomly, the females sacrificed after
Zheng Zhang et al.
The Journal of reproduction and development, 55(1), 94-97 (2008-11-22)
Embryos transfer is one of the most critical steps for generating genetically modified mice. Because of the limitations of the current transfer equipment and techniques, such as discharge of freshly transferred embryos and the necessity of sophisticated transfer skills, the
Genetic-engineered models of skeletal diseases. II. Targeting mutations into transgenic mice chondrocytes.
S Garofalo et al.
Methods in molecular biology (Clifton, N.J.), 137, 491-498 (2000-08-19)
Alberto Joven et al.
Methods in molecular biology (Clifton, N.J.), 1290, 47-70 (2015-03-06)
Research on urodele amphibians, such as newts, is constantly contributing to our understanding of fundamental biological processes. In the present chapter, we present detailed husbandry protocols for the Spanish ribbed newt (Pleurodeles waltl ). We describe the main phases of their
实验方案
利用 CRISPR-Cas9 基因组编辑技术创建转基因小鼠
Creating Transgenic Mice using CRISPR-Cas9 Genome Editing
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门