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C7370

Sigma-Aldrich

CAMKK2, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

别名:

CAMKKβ, KIAA0787, MGC15254

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About This Item

分類程式碼代碼:
12352200
NACRES:
NA.32

重組細胞

expressed in baculovirus infected Sf9 cells

品質等級

200

產品線

PRECISIO® Kinase

化驗

≥70% (SDS-PAGE)

形狀

buffered aqueous glycerol solution

比活性

9-13 nmol/min·mg

分子量

~88 kDa

UniProt登錄號

Q96RR4

運輸包裝

dry ice

儲存溫度

−70°C

基因資訊

human ... CAMKK2(10645)

生化／生理作用

CAMKK2 (CAMKKb) is a member of the CAMKK family. It is broadly distributed in tissues with highest levels in brain, thymus, spleen, and testis. CAMKK2 undergoes intramolecular autophosphorylation, is regulated by Ca2+/calmodulin and phosphorylates CAMKI and CAMKIV on Thr177 and Thr200, respectively. CAMKK2 activates both CAMKI and CAMKIV when coexpressed in Jurkat T cells. CAMKK2 also phosphorylates and regulates the activity of AMPK, which is an important regulator of cellular metabolism in response to metabolic stress.

外觀

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

法律資訊

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Brian York et al.
Scientific reports, 7(1), 11793-11793 (2017-09-20)
Binding of calcium to its intracellular receptor calmodulin (CaM) activates a family of Ca
K A Anderson et al.
The Journal of biological chemistry, 273(48), 31880-31889 (1998-11-21)
Ca2+/calmodulin-dependent protein kinases I and IV (CaMKI and CaMKIV, respectively) require phosphorylation on an equivalent single Thr in the activation loop of subdomain VIII for maximal activity. Two distinct CaMKI/IV kinases, CaMKKalpha and CaMKKbeta, were purified from rat brain and
Rebecca L Hurley et al.
The Journal of biological chemistry, 280(32), 29060-29066 (2005-06-28)
The AMP-activated protein kinase (AMPK) is an important regulator of cellular metabolism in response to metabolic stress and to other regulatory signals. AMPK activity is absolutely dependent upon phosphorylation of AMPKalphaThr-172 in its activation loop by one or more AMPK

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