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Merck
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文件

C6830

Sigma-Aldrich

抗菌肽A

≥97% (HPLC), powder

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About This Item

经验公式（希尔记法）:
C184H313N53O46
CAS号:
80451-04-3
分子量:
4003.78
MDL號碼:
MFCD00130752
分類程式碼代碼:
12352202
NACRES:
NA.32

品質等級

200

化驗

≥97% (HPLC)

形狀

powder

抗生素活性譜

fungi
viruses

作用方式

cell membrane | interferes

儲存溫度

−20°C

InChI

1S/C184H313N53O46/c1-27-98(16)145(182(282)235-149(102(20)31-5)181(281)218-115(59-39-46-76-187)159(259)206-103(21)152(252)205-92-138(246)237-82-52-65-130(237)173(273)208-106(24)154(254)228-143(96(12)13)176(276)209-107(25)155(255)229-144(97(14)15)177(277)231-142(95(10)11)175(275)204-89-135(243)211-121(66-70-131(193)239)160(260)207-105(23)156(256)236-150(108(26)238)183(283)221-123(68-72-133(195)241)168(268)232-146(99(17)28-2)178(278)210-104(22)153(253)213-114(151(197)251)58-38-45-75-186)227-137(245)91-202-158(258)129(87-140(249)250)226-163(263)120(64-51-81-200-184(198)199)219-179(279)148(101(19)30-4)234-172(272)128(86-134(196)242)225-164(264)122(67-71-132(194)240)212-136(244)90-203-174(274)141(94(8)9)230-166(266)118(62-42-49-79-190)215-165(265)124(69-73-139(247)248)220-180(280)147(100(18)29-3)233-167(267)119(63-43-50-80-191)214-161(261)116(60-40-47-77-188)216-170(270)126(84-109-53-33-32-34-54-109)224-169(269)125(83-93(6)7)223-162(262)117(61-41-48-78-189)217-171(271)127(222-157(257)112(192)56-37-44-74-185)85-110-88-201-113-57-36-35-55-111(110)113/h32-36,53-55,57,88,93-108,112,114-130,141-150,201,238H,27-31,37-52,56,58-87,89-92,185-192H2,1-26H3,(H2,193,239)(H2,194,240)(H2,195,241)(H2,196,242)(H2,197,251)(H,202,258)(H,203,274)(H,204,275)(H,205,252)(H,206,259)(H,207,260)(H,208,273)(H,209,276)(H,210,278)(H,211,243)(H,212,244)(H,213,253)(H,214,261)(H,215,265)(H,216,270)(H,217,271)(H,218,281)(H,219,279)(H,220,280)(H,221,283)(H,222,257)(H,223,262)(H,224,269)(H,225,264)(H,226,263)(H,227,245)(H,228,254)(H,229,255)(H,230,266)(H,231,277)(H,232,268)(H,233,267)(H,234,272)(H,235,282)(H,236,256)(H,247,248)(H,249,250)(H4,198,199,200)/t98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108+,112-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-/m0/s1

InChI 密鑰

HCQPHKMLKXOJSR-IRCPFGJUSA-N

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Amino Acid Sequence

Lys-Trp-Lys-Leu-Phe-Lys-Lys-Ile-Glu-Lys-Val-Gly-Gln-Asn-Ile-Arg-Asp-Gly-Ile-Ile-Lys-Ala-Gly-Pro-Ala-Val-Ala-Val-Val-Gly-Gln-Ala-Thr-Gln-Ile-Ala-Lys-NH2

一般說明

天蚕素A属于天蚕素类，由L构象的37个氨基酸残基组成。结构上，该肽具有一个C端的疏水α-螺旋结构和两亲性的N端。天蚕素A是线性的，具有阳离子属性。

應用

天蚕素A已作为一种抗菌肽（AMP）被用于：
  • 检测其对乳腺癌（MDA-MB-231）和人间皮瘤（M14K）细胞系的细胞毒性作用
  • 在针对大肠杆菌的超灵敏发射扩散测定中用于检测大蜡螟蛋白24和apolipophorin III的作用
  • 在针对光杆状菌变种的灵敏度测定中用于检测最小抑制浓度（MIC）

生化／生理作用

天蚕素A可与细胞膜发生相互作用，使其对电解质具有渗透性。因此，天蚕素A在肝细胞癌和淋巴瘤中有助于细胞溶解并最终导致细胞死亡。在转基因水稻中的这种合成型天蚕素A具有抗细菌和真菌病原体的作用。
最初在飞蛾（刻克罗普斯蚕蛾）中鉴定出的抗菌肽随后在猪肠中也被鉴定出来。

其他說明

从0.1％TFA水溶液中冻干

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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Xiuqing Wang et al.
Experimental biology and medicine (Maywood, N.J.), 237(3), 312-317 (2012-03-02)
The hybrid peptide CA(1-7)-M(2-12) gene was designed according to the N-terminal 1-7 amino acid sequence of the antimicrobial peptide cecropin A (CA) and the N-terminal 2-12 amino acid sequence of maganin (M) and synthesized using Pichia pastoris preferred codons. The
Sequence and specificity of two antibacterial proteins involved in insect immunity. Nature 292: 246-248. 1981.
Håkan Steiner et al.
Journal of immunology (Baltimore, Md. : 1950), 182(11), 6635-6637 (2009-05-21)
Sichen Shao et al.
Cell, 147(7), 1576-1588 (2011-12-27)
Metazoans secrete an extensive array of small proteins essential for intercellular communication, defense, and physiologic regulation. Their synthesis takes mere seconds, leaving minimal time for recognition by the machinery for cotranslational protein translocation into the ER. The pathway taken by
Loredana Mereuta et al.
Langmuir : the ACS journal of surfaces and colloids, 28(49), 17079-17091 (2012-11-13)
Metal ions binding exert a crucial influence upon the aggregation properties and stability of peptides, and the propensity of folding in various substates. Herein, we demonstrate the use of the α-HL protein as a powerful nanoscopic tool to probe Cu(2+)-triggered
Fatima Cairrao et al.
Molecular and cellular biology, 29(10), 2636-2643 (2009-03-11)
In mammals, AU-rich elements (AREs) are critical regulators of mRNA turnover. They recruit ARE-binding proteins that inhibit or stimulate rapid mRNA degradation in response to stress or developmental cues. Using a bioinformatics approach, we have identified AREs in Drosophila melanogaster
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