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Merck
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Key Documents

C6499

Sigma-Aldrich

CTB

≥98% (HPLC)

别名:

CTPB, N-(4-氯-3-三氟甲基-苯基)-2-乙氧基-苯甲酰胺

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About This Item

经验公式(希尔记法):
C16H13ClF3NO2
分子量:
343.73
分類程式碼代碼:
12352200
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

white to off-white

溶解度

DMSO: >10 mg/mL

儲存溫度

2-8°C

一般說明

CTB(N-(4-氯-3-三氟甲基-苯基)-2-乙氧基-苯甲酰胺)来源于漆树酸。

應用

CTB 已用于研究其P53 蛋白乙酰化的凋亡作用。

生化/生理作用

CTPB 是第一个已知的组蛋白乙酰转移酶 p300 的小分子激活剂。CTB 是 CTPB 的一种简化类似物,具有相当或更高的活性。该化合物激活 p300/EP300/E1A 结合蛋白的组蛋白乙酰转移酶 (HAT) 活性。
HAT 的小分子激活剂如 CTB(N-(4-氯-3-三氟甲基-苯基)-2-乙氧基-苯甲酰胺)可直接改变染色质乙酰化。可作为治疗神经精神、神经发育和神经退行性疾病等认知功能障碍并发症的药物。

特點和優勢

这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2


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